Evaluation of hyperpolarized [1-¹³C]-pyruvate by magnetic resonance to detect ionizing radiation effects in real time.

Evaluation of hyperpolarized [1-¹³C]-pyruvate by magnetic resonance to detect ionizing radiation effects in real time.

Ionizing radiation (IR) cytotoxicity is primarily mediated through reactive oxygen species (ROS). Since tumor cells neutralize ROS by utilizing reducing equivalents, we hypothesized that measurements of reducing potential using real-time hyperpolarized (HP) magnetic resonance spectroscopy (MRS) and...

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Bibliographic Details
Main Authors: Vlad C Sandulache, Yunyun Chen, Jaehyuk Lee, Ashley Rubinstein, Marc S Ramirez, Heath D Skinner, Christopher M Walker, Michelle D Williams, Ramesh Tailor, Laurence E Court, James A Bankson, Stephen Y Lai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3903593?pdf=render

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http://europepmc.org/articles/PMC3903593?pdf=render

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