Lower waist circumference in mildly‐stunted adolescents is associated with elevated insulin concentration
Objective: Augmented waist circumference (WC) is associated with non‐communicable diseases and could represent a valuable marker in screening for metabolic dysfunctions in subjects with insufficient linear growth. The objective of the present study was to determine whether biochemical and hemodynami...
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doaj-5cf7faf2bcb74d5a91b140138ad759e52020-11-24T21:32:25ZporElsevierJornal de Pediatria (Versão em Português)2255-55362014-09-0190547948510.1016/j.jpedp.2014.07.001Lower waist circumference in mildly‐stunted adolescents is associated with elevated insulin concentrationAna Paula Grotti Clemente0Carla Danusa da Luz Santos1Vinicius J.B. Martins2Maria Paula Albuquerque3Mariana B. Fachim4Ana Lydia Sawaya5Universidade Federal de Alagoas (UFAL), Maceió, AL, BrasilCiências Aplicadas à Pediatria, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, BrasilPrograma de Pós‐graduação em Endocrinologia Clínica, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, BrasilPrograma de Pós‐graduação em Endocrinologia Clínica, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, BrasilUniversidade Federal de São Paulo (UNIFESP), São Paulo, SP, BrasilDepartamento de Fisiologia, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, BrasilObjective: Augmented waist circumference (WC) is associated with non‐communicable diseases and could represent a valuable marker in screening for metabolic dysfunctions in subjects with insufficient linear growth. The objective of the present study was to determine whether biochemical and hemodynamic parameters and waist circumference vary between mildly‐stunted and non‐stunted adolescents from impoverished communities of São Paulo, Brazil. Methods: The cross‐sectional study involved 206 subjects, aged between 9 and 19 years and living in impoverished areas of São Paulo, Brazil. The sample population was divided according to height‐for‐age Z‐score (HAZ) into stunted (–1 > HAZ ≥ –2) and non‐stunted (HAZ ≥ –1) groups, and was sub‐divided according to gender. Logistic regression analysis was employed to compare individuals with elevated (> 75th percentile) insulin concentrations. The receiver operating characteristic curves were constructed to determine WC cut‐off points that could be used to identify stunted and non‐stunted individuals with elevated insulin concentrations. Results: WC cut‐off points of 58.25 cm and 67.2 cm allowed for correct classification of 90.7% of stunted and 88.7% of non‐stunted individuals in the studied population. While the sensitivity of the model was high for stunted and non‐stunted subjects (98.8% and 97.2%, respectively), the specificity was modest (57.1% and 41.2%, respectively). Conclusion: The results presented herein suggest that an increase in plasma insulin is one of the primary metabolic modifications in stunted individuals, and that this alteration could be identified at a lower WC cut‐off point than in non‐stunted counterparts.http://www.sciencedirect.com/science/article/pii/S2255553614001141Waist circumferenceHeightInsulin |
collection |
DOAJ |
language |
Portuguese |
format |
Article |
sources |
DOAJ |
author |
Ana Paula Grotti Clemente Carla Danusa da Luz Santos Vinicius J.B. Martins Maria Paula Albuquerque Mariana B. Fachim Ana Lydia Sawaya |
spellingShingle |
Ana Paula Grotti Clemente Carla Danusa da Luz Santos Vinicius J.B. Martins Maria Paula Albuquerque Mariana B. Fachim Ana Lydia Sawaya Lower waist circumference in mildly‐stunted adolescents is associated with elevated insulin concentration Jornal de Pediatria (Versão em Português) Waist circumference Height Insulin |
author_facet |
Ana Paula Grotti Clemente Carla Danusa da Luz Santos Vinicius J.B. Martins Maria Paula Albuquerque Mariana B. Fachim Ana Lydia Sawaya |
author_sort |
Ana Paula Grotti Clemente |
title |
Lower waist circumference in mildly‐stunted adolescents is associated with elevated insulin concentration |
title_short |
Lower waist circumference in mildly‐stunted adolescents is associated with elevated insulin concentration |
title_full |
Lower waist circumference in mildly‐stunted adolescents is associated with elevated insulin concentration |
title_fullStr |
Lower waist circumference in mildly‐stunted adolescents is associated with elevated insulin concentration |
title_full_unstemmed |
Lower waist circumference in mildly‐stunted adolescents is associated with elevated insulin concentration |
title_sort |
lower waist circumference in mildly‐stunted adolescents is associated with elevated insulin concentration |
publisher |
Elsevier |
series |
Jornal de Pediatria (Versão em Português) |
issn |
2255-5536 |
publishDate |
2014-09-01 |
description |
Objective: Augmented waist circumference (WC) is associated with non‐communicable diseases and could represent a valuable marker in screening for metabolic dysfunctions in subjects with insufficient linear growth. The objective of the present study was to determine whether biochemical and hemodynamic parameters and waist circumference vary between mildly‐stunted and non‐stunted adolescents from impoverished communities of São Paulo, Brazil.
Methods: The cross‐sectional study involved 206 subjects, aged between 9 and 19 years and living in impoverished areas of São Paulo, Brazil. The sample population was divided according to height‐for‐age Z‐score (HAZ) into stunted (–1 > HAZ ≥ –2) and non‐stunted (HAZ ≥ –1) groups, and was sub‐divided according to gender. Logistic regression analysis was employed to compare individuals with elevated (> 75th percentile) insulin concentrations. The receiver operating characteristic curves were constructed to determine WC cut‐off points that could be used to identify stunted and non‐stunted individuals with elevated insulin concentrations.
Results: WC cut‐off points of 58.25 cm and 67.2 cm allowed for correct classification of 90.7% of stunted and 88.7% of non‐stunted individuals in the studied population. While the sensitivity of the model was high for stunted and non‐stunted subjects (98.8% and 97.2%, respectively), the specificity was modest (57.1% and 41.2%, respectively).
Conclusion: The results presented herein suggest that an increase in plasma insulin is one of the primary metabolic modifications in stunted individuals, and that this alteration could be identified at a lower WC cut‐off point than in non‐stunted counterparts. |
topic |
Waist circumference Height Insulin |
url |
http://www.sciencedirect.com/science/article/pii/S2255553614001141 |
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