Signaling, Polyubiquitination, Trafficking, and Inclusions: Sequestosome 1/p62's Role in Neurodegenerative Disease

Signaling, Polyubiquitination, Trafficking, and Inclusions: Sequestosome 1/p62's Role in Neurodegenerative Disease

Aggregated misfolded proteins are hallmarks of most neurodegenerative diseases. In a chronic disease state, including pathologic situations of oxidative stress, these proteins are sequestered into inclusions. Accumulation of aggregated proteins can be prevented by chaperones, or by targeting their d...

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Bibliographic Details
Main Authors:	Marie W. Wooten, Xiao Hu, J. Ramesh Babu, M. Lamar Seibenhener, Thangiah Geetha, Michael G. Paine, Michael C. Wooten
Format:	Article
Language:	English
Published:	Hindawi Limited 2006-01-01
Series:	Journal of Biomedicine and Biotechnology
Online Access:	http://dx.doi.org/10.1155/JBB/2006/62079

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