Changes of bone mineral density, bone metabolism indices and cell factors in patients with hyperthyroidism
Objective: To observe the changes of bone mineral density, bone metabolism indices and cell factor in patients with hyperthyroidism Methods: A total of 116 cases of hyperthyroidism patients from June 2015 to June 2016 in our hospital were selected. as the object of observation group. Then, 120 ca...
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doaj-5d047832ce58475b8d62f7acdf6fcad72020-11-25T00:28:57ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12372017-02-01232127130Changes of bone mineral density, bone metabolism indices and cell factors in patients with hyperthyroidismDan Lu0Xiao-Xi Wang1Han-Ling Ying2Department of Endocrinology of Deyang People's Hospital of Sichuan Province, De Yang, Si Chuan 618000Department of Endocrinology of Deyang People's Hospital of Sichuan Province, De Yang, Si Chuan 618000Department of Endocrinology of Deyang People's Hospital of Sichuan Province, De Yang, Si Chuan 618000Objective: To observe the changes of bone mineral density, bone metabolism indices and cell factor in patients with hyperthyroidism Methods: A total of 116 cases of hyperthyroidism patients from June 2015 to June 2016 in our hospital were selected. as the object of observation group. Then, 120 cases of healthy people were selected as the object of control group. Thyroid function indexes (TT3, TT4, FT3, FT4, TSH), bone mineral density (BMD), bone metabolism indexes (PTH, BGP, PINP) and cell factors (IL-2, IL-6) in both groups were detected and compared. Results: TT3, TT4, FT3, FT4, TSH in control group were (1.40±0.81) nmol/ L, (94.36±32.10) nmol/L, (5.04±1.18) pmol/L, (15.37±4.60) pmol/L, (2.55±1.21) mU/L. TT3, TT4, FT3, FT4, TSH in observation group were (5.48±2.36) nmol/L, (405.55±71.48) nmol/L, (16.27±5.14) pmol/L, (46.83±12.66) pmol/L, (0.04±0.01) mU/L. TT3, TT4, FT3, FT4 in the observation group were higher than that in control group obviously. TSH in the observation group was lower than that in observation group obviously. The difference between two groups was considered statistically significant. BMD, PTH in observation group were (0.62±0.08) g/m2, (26.25±9.16) pg/mL, which were obviously lower than BMD (1.23±0.11) g/m2, PTH (37.13±8.05) pg/mL in control group. The difference between two groups was considered statistically significant. BGP, PINP in observation group were (14.51±6.25) ng/ mL, (223.63±10.38) μg/L, which were obviously higher than BGP (5.97±1.98) ng/mL, PINP (33.18±6.15) μg/L in control group. The difference between two groups was considered statistically significant. IL-2 in observation group was (1.60±0.51) ng/L, which was obviously lower than IL-2 (4.72±1.29) ng/L, in control group. IL-6 in observation group was (1.98±0.34) pg/L, which was obviously higher than IL-6, (1.50±0.23) pg/L, in control group. The difference between two groups was considered statistically significant. Conclusion: Bone mineral density in patients with hyperthyroidism decreased and bone metabolism in patients with hyperthyroidism was active. The significant changes of IL-2, IL-6 also can be seen. In the clinical ,We should enhance the detection of these indexes, so as to take measures to prevent and cure the complications such as osteoporosis.http://www.hnykdxxb.com/PDF/201702/31.pdfHyperthyroidismBone mineral densityBone metabolism indictsCell factors |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dan Lu Xiao-Xi Wang Han-Ling Ying |
spellingShingle |
Dan Lu Xiao-Xi Wang Han-Ling Ying Changes of bone mineral density, bone metabolism indices and cell factors in patients with hyperthyroidism Journal of Hainan Medical University Hyperthyroidism Bone mineral density Bone metabolism indicts Cell factors |
author_facet |
Dan Lu Xiao-Xi Wang Han-Ling Ying |
author_sort |
Dan Lu |
title |
Changes of bone mineral density, bone metabolism indices and cell factors in patients with hyperthyroidism |
title_short |
Changes of bone mineral density, bone metabolism indices and cell factors in patients with hyperthyroidism |
title_full |
Changes of bone mineral density, bone metabolism indices and cell factors in patients with hyperthyroidism |
title_fullStr |
Changes of bone mineral density, bone metabolism indices and cell factors in patients with hyperthyroidism |
title_full_unstemmed |
Changes of bone mineral density, bone metabolism indices and cell factors in patients with hyperthyroidism |
title_sort |
changes of bone mineral density, bone metabolism indices and cell factors in patients with hyperthyroidism |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 |
publishDate |
2017-02-01 |
description |
Objective: To observe the changes of bone mineral density, bone metabolism indices and cell
factor in patients with hyperthyroidism Methods: A total of 116 cases of hyperthyroidism
patients from June 2015 to June 2016 in our hospital were selected. as the object of observation
group. Then, 120 cases of healthy people were selected as the object of control group. Thyroid
function indexes (TT3, TT4, FT3, FT4, TSH), bone mineral density (BMD), bone metabolism
indexes (PTH, BGP, PINP) and cell factors (IL-2, IL-6) in both groups were detected and
compared. Results: TT3, TT4, FT3, FT4, TSH in control group were (1.40±0.81) nmol/
L, (94.36±32.10) nmol/L, (5.04±1.18) pmol/L, (15.37±4.60) pmol/L, (2.55±1.21) mU/L.
TT3, TT4, FT3, FT4, TSH in observation group were (5.48±2.36) nmol/L, (405.55±71.48)
nmol/L, (16.27±5.14) pmol/L, (46.83±12.66) pmol/L, (0.04±0.01) mU/L. TT3, TT4, FT3,
FT4 in the observation group were higher than that in control group obviously. TSH in the
observation group was lower than that in observation group obviously. The difference between
two groups was considered statistically significant. BMD, PTH in observation group were
(0.62±0.08) g/m2, (26.25±9.16) pg/mL, which were obviously lower than BMD (1.23±0.11)
g/m2, PTH (37.13±8.05) pg/mL in control group. The difference between two groups was
considered statistically significant. BGP, PINP in observation group were (14.51±6.25) ng/
mL, (223.63±10.38) μg/L, which were obviously higher than BGP (5.97±1.98) ng/mL, PINP
(33.18±6.15) μg/L in control group. The difference between two groups was considered
statistically significant. IL-2 in observation group was (1.60±0.51) ng/L, which was obviously
lower than IL-2 (4.72±1.29) ng/L, in control group. IL-6 in observation group was (1.98±0.34)
pg/L, which was obviously higher than IL-6, (1.50±0.23) pg/L, in control group. The
difference between two groups was considered statistically significant. Conclusion: Bone
mineral density in patients with hyperthyroidism decreased and bone metabolism in patients
with hyperthyroidism was active. The significant changes of IL-2, IL-6 also can be seen. In the
clinical ,We should enhance the detection of these indexes, so as to take measures to prevent
and cure the complications such as osteoporosis. |
topic |
Hyperthyroidism Bone mineral density Bone metabolism indicts Cell factors |
url |
http://www.hnykdxxb.com/PDF/201702/31.pdf |
work_keys_str_mv |
AT danlu changesofbonemineraldensitybonemetabolismindicesandcellfactorsinpatientswithhyperthyroidism AT xiaoxiwang changesofbonemineraldensitybonemetabolismindicesandcellfactorsinpatientswithhyperthyroidism AT hanlingying changesofbonemineraldensitybonemetabolismindicesandcellfactorsinpatientswithhyperthyroidism |
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1725333500246097920 |