Succinimides: Synthesis, properties and anticonvulsant activity

• Main Authors: Banjac Nebojša, Trišović Nemanja, Valentić Nataša, Ušćumlić Gordana, Petrović Slobodan
• Format: Article
• Language: English
• Published: Association of Chemical Engineers of Serbia 2011-01-01
• Series: Hemijska Industrija
• Subjects: succinimide; properties; reactivity; sythesis; zarontin; celontin; milontin; anticonvulsant activity; pharmacofor model; lipophilicity; hydrogen bonding
• Online Access: http://www.doiserbia.nb.rs/img/doi/0367-598X/2011/0367-598X1100030B.pdf

Succinimide is a cycle imide of succinic acid that is present in numerous biologically active compounds including anticonvulsants, antitremor, anti-Parkinson`s agents. This paper describes different ways of synthesis of succinimide-derivatives their physical properties and reactivity. Also, the most widely used succinimide anticonvulsants and the analysis of structure-activity relationships of anticonvulsant drugs in terms of lipophilicity and hydrogen bonding are presented here.