The Effect of Tribulus Terrestris Extract on Hepatic Complications Due to the Gelofen Consumption in Adult Female Rats
Background & Objective: Gelofen is one of the anti-inflammatory drugs which is used to relieve the pain and reduce the inflammations. This drug has side effects on body's tissues. This study aimed to investigate the effect of Tribulus terrestris (Tt) plant on hepatic transaminases due to th...
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Fasa University of Medical Sciences
2016-09-01
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doaj-5d0f1fc48c4446a6a9372d2fbc2d34482020-11-24T22:09:15ZfasFasa University of Medical SciencesJournal of Fasa University of Medical Sciences2228-51052228-73292016-09-0162155161The Effect of Tribulus Terrestris Extract on Hepatic Complications Due to the Gelofen Consumption in Adult Female RatsLeila Hejazi0Ebrahim Hosseini1 Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran Background & Objective: Gelofen is one of the anti-inflammatory drugs which is used to relieve the pain and reduce the inflammations. This drug has side effects on body's tissues. This study aimed to investigate the effect of Tribulus terrestris (Tt) plant on hepatic transaminases due to the Gelofen consumption. Materials & Methods: In this experimental study 56 rats were divided into 7 groups of 8 rats, including control, sham and 4 experimental groups receiving Gelofen 400mg / kg, Tt extract 80 mg / kg, Tt extract 20mg / kg and Gelofen with 400mg / kg doses, Tt extract 40mg / kg and Gelofen 400mg / kg, and Tt extract 80mg / kg and Gelofen 400mg / kg. Gelofen was prescribed intraperitoneal and Tt was prescribed orally for 21 days. At the end of phlebotomizing the animals, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and Anaplastic lymphoma kinase (ALK) levels were measured, and the results were analyzed by ANOVA and Duncan tests. The significant difference in the data was considered P> 0/05. Results: The results showed that the transaminase concentration in the groups receiving Gelofen alone and with the Tt extract in doses of 20mg /kg and 40 mg /kg had a significant increase compared to the control group and the groups receiving Tt alone and Tt with the dose of 80mg/kg with Gelofen,had a significant decrease compared to the control and Gelofen alone groups (P> 0/05). Conclusion: The results showed that the Tt extract led to prevent the negative effects of Gelofen on hepatic tissue in a dose-dependent manner and in result on the serum levels of liver transaminases.http://journal.fums.ac.ir/browse.php?a_code=A-10-72-4&slc_lang=en&sid=1Gelofen Tribulus terrestris ALT AST ALK Rat |
collection |
DOAJ |
language |
fas |
format |
Article |
sources |
DOAJ |
author |
Leila Hejazi Ebrahim Hosseini |
spellingShingle |
Leila Hejazi Ebrahim Hosseini The Effect of Tribulus Terrestris Extract on Hepatic Complications Due to the Gelofen Consumption in Adult Female Rats Journal of Fasa University of Medical Sciences Gelofen Tribulus terrestris ALT AST ALK Rat |
author_facet |
Leila Hejazi Ebrahim Hosseini |
author_sort |
Leila Hejazi |
title |
The Effect of Tribulus Terrestris Extract on Hepatic Complications Due to the Gelofen Consumption in Adult Female Rats |
title_short |
The Effect of Tribulus Terrestris Extract on Hepatic Complications Due to the Gelofen Consumption in Adult Female Rats |
title_full |
The Effect of Tribulus Terrestris Extract on Hepatic Complications Due to the Gelofen Consumption in Adult Female Rats |
title_fullStr |
The Effect of Tribulus Terrestris Extract on Hepatic Complications Due to the Gelofen Consumption in Adult Female Rats |
title_full_unstemmed |
The Effect of Tribulus Terrestris Extract on Hepatic Complications Due to the Gelofen Consumption in Adult Female Rats |
title_sort |
effect of tribulus terrestris extract on hepatic complications due to the gelofen consumption in adult female rats |
publisher |
Fasa University of Medical Sciences |
series |
Journal of Fasa University of Medical Sciences |
issn |
2228-5105 2228-7329 |
publishDate |
2016-09-01 |
description |
Background & Objective: Gelofen is one of the anti-inflammatory drugs which is used to relieve the pain and reduce the inflammations. This drug has side effects on body's tissues. This study aimed to investigate the effect of Tribulus terrestris (Tt) plant on hepatic transaminases due to the Gelofen consumption.
Materials & Methods: In this experimental study 56 rats were divided into 7 groups of 8 rats, including control, sham and 4 experimental groups receiving Gelofen 400mg / kg, Tt extract 80 mg / kg, Tt extract 20mg / kg and Gelofen with 400mg / kg doses, Tt extract 40mg / kg and Gelofen 400mg / kg, and Tt extract 80mg / kg and Gelofen 400mg / kg. Gelofen was prescribed intraperitoneal and Tt was prescribed orally for 21 days. At the end of phlebotomizing the animals, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and Anaplastic lymphoma kinase (ALK) levels were measured, and the results were analyzed by ANOVA and Duncan tests. The significant difference in the data was considered P> 0/05.
Results: The results showed that the transaminase concentration in the groups receiving Gelofen alone and with the Tt extract in doses of 20mg /kg and 40 mg /kg had a significant increase compared to the control group and the groups receiving Tt alone and Tt with the dose of 80mg/kg with Gelofen,had a significant decrease compared to the control and Gelofen alone groups (P> 0/05).
Conclusion: The results showed that the Tt extract led to prevent the negative effects of Gelofen on hepatic tissue in a dose-dependent manner and in result on the serum levels of liver transaminases. |
topic |
Gelofen Tribulus terrestris ALT AST ALK Rat |
url |
http://journal.fums.ac.ir/browse.php?a_code=A-10-72-4&slc_lang=en&sid=1 |
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