Adiponectin Modified BMSCs Alleviate Heart Fibrosis via Inhibition TGF-beta1/Smad in Diabetic Rats

Adiponectin Modified BMSCs Alleviate Heart Fibrosis via Inhibition TGF-beta1/Smad in Diabetic Rats

Background: Accumulating evidence suggested that bone marrow mesenchymal stem cells (BMSCs) have therapeutic potential for diabetes and heart diseases. However, the effects of BMSC on reducing myocardial fibrosis need to be optimized. This study aimed to investigate the mechanism of adiponectin (APN...

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Bibliographic Details
Main Authors: Ke Meng, Huabo Cai, Simin Cai, Yucai Hong, Xiaoming Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
diabetic cardiomyopathy
adiponectin
bone marrow mesenchymal stem cells
TGF-beta1
myocardial fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.644160/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.644160/full

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