Smart niosomes of temozolomide for enhancement of brain targeting
Drug delivery to the brain is challenging because of the low permeability of blood–brain barrier, and therefore, optimum concentration of chemotherapeutics in the target area specifically for glioblastoma, an aggressive brain tumor, opens a new path of research. To achieve the goal, the oral alkylat...
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Online Access: | https://doi.org/10.1177/1849543518805355 |
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doaj-5d1cb60acf28488a9a264e789e91ed402020-11-25T03:09:33ZengSAGE PublishingNanobiomedicine1849-54352018-10-01510.1177/1849543518805355Smart niosomes of temozolomide for enhancement of brain targetingAnindita De0Nagasamy Venkatesh1M Senthil2Bharat Kumar Reddy Sanapalli3R Shanmugham4Veera Venkata Satyanarayana Reddy Karri5 Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India Department of Pharmaceutical Analysis, Sree Vidyanikethan College of Pharmacy, Tirupati, Jawaharlal Nehru Technological University Ananthapur, Andhra Pradesh, India Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund, JSS Academy of Higher Education & Research, Mysuru, Karnataka, IndiaDrug delivery to the brain is challenging because of the low permeability of blood–brain barrier, and therefore, optimum concentration of chemotherapeutics in the target area specifically for glioblastoma, an aggressive brain tumor, opens a new path of research. To achieve the goal, the oral alkylating agent temozolomide was incorporated into niosomes, and the surface was modified with chlorotoxin, a small 36 amino acid peptide discovered from the venom of scorpion Leiurus quinquestriatus . Active targeting using nanosized particles facilitates an increase in the accumulation of drugs in the cerebri by 3.04-folds. Temozolomide-loaded niosomes were prepared using conventional thin-film hydration method and characterized. Niosomes coated with chlorotoxin were produced with the size of 220 ± 1.45 nm with an entrapment efficiency of 79.09 ± 1.56%. Quantitative tissue distribution studies indicate enhanced permeation of the drug into the brain because of surface modification with less deposition in the highly perfused organs.https://doi.org/10.1177/1849543518805355 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anindita De Nagasamy Venkatesh M Senthil Bharat Kumar Reddy Sanapalli R Shanmugham Veera Venkata Satyanarayana Reddy Karri |
spellingShingle |
Anindita De Nagasamy Venkatesh M Senthil Bharat Kumar Reddy Sanapalli R Shanmugham Veera Venkata Satyanarayana Reddy Karri Smart niosomes of temozolomide for enhancement of brain targeting Nanobiomedicine |
author_facet |
Anindita De Nagasamy Venkatesh M Senthil Bharat Kumar Reddy Sanapalli R Shanmugham Veera Venkata Satyanarayana Reddy Karri |
author_sort |
Anindita De |
title |
Smart niosomes of temozolomide for enhancement of brain targeting |
title_short |
Smart niosomes of temozolomide for enhancement of brain targeting |
title_full |
Smart niosomes of temozolomide for enhancement of brain targeting |
title_fullStr |
Smart niosomes of temozolomide for enhancement of brain targeting |
title_full_unstemmed |
Smart niosomes of temozolomide for enhancement of brain targeting |
title_sort |
smart niosomes of temozolomide for enhancement of brain targeting |
publisher |
SAGE Publishing |
series |
Nanobiomedicine |
issn |
1849-5435 |
publishDate |
2018-10-01 |
description |
Drug delivery to the brain is challenging because of the low permeability of blood–brain barrier, and therefore, optimum concentration of chemotherapeutics in the target area specifically for glioblastoma, an aggressive brain tumor, opens a new path of research. To achieve the goal, the oral alkylating agent temozolomide was incorporated into niosomes, and the surface was modified with chlorotoxin, a small 36 amino acid peptide discovered from the venom of scorpion Leiurus quinquestriatus . Active targeting using nanosized particles facilitates an increase in the accumulation of drugs in the cerebri by 3.04-folds. Temozolomide-loaded niosomes were prepared using conventional thin-film hydration method and characterized. Niosomes coated with chlorotoxin were produced with the size of 220 ± 1.45 nm with an entrapment efficiency of 79.09 ± 1.56%. Quantitative tissue distribution studies indicate enhanced permeation of the drug into the brain because of surface modification with less deposition in the highly perfused organs. |
url |
https://doi.org/10.1177/1849543518805355 |
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