Current progress of the inflammasomes in aortic aneurysm and aortic dissection

Current progress of the inflammasomes in aortic aneurysm and aortic dissection

Objective: ToAortic aneurysm (AA) is the permanent, irreversible, asymmetrical arterial dilation to at least 50% of the normal diameter. Aortic dissection (AD) may occur when the aorta enlarges to reach the tensile limit, which is the most lethal condition because of its rapid progression and hig...

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Main Authors: Jun Cui, Fang Bian
Format: Article
Language:English
Published: Editorial Board of Journal of Hainan Medical University 2018-11-01
Series:Journal of Hainan Medical University
Subjects:
Essential hypertension
ECG Cornell voltage
Left ventricle hypertrophy
Online Access:http://www.hnykdxxb.com/PDF/201811/21.pdf
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spelling doaj-5d1e867c5a2947bf8a837ed83c1493352020-11-24T21:44:30ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372018-11-0124118488Current progress of the inflammasomes in aortic aneurysm and aortic dissectionJun Cui0Fang Bian1Department of Cardiothoracic Surgery, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Hubei Xiangyang 441021Department of Pharmacology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Hubei Xiangyang 441021Objective: ToAortic aneurysm (AA) is the permanent, irreversible, asymmetrical arterial dilation to at least 50% of the normal diameter. Aortic dissection (AD) may occur when the aorta enlarges to reach the tensile limit, which is the most lethal condition because of its rapid progression and high mortality. There is no doubt that inflammation is involved in the pathogenesis of AA and AD. Inflammasome, a large multi-protein complex in the cytosol regulating interleukin-1β (IL-1β) production, has critical roles on the pathogenesis of cardiovascular diseases. This review aims to summarize the current progress of the inflammasomes on AA/AD-related proteins and signal pathways to further explore the role of the inflammasomes in the progression of AA and AD.http://www.hnykdxxb.com/PDF/201811/21.pdf Essential hypertensionECG Cornell voltageLeft ventricle hypertrophy
collection DOAJ
language English
format Article
sources DOAJ
author Jun Cui
Fang Bian
spellingShingle Jun Cui
Fang Bian
Current progress of the inflammasomes in aortic aneurysm and aortic dissection
Journal of Hainan Medical University
Essential hypertension
ECG Cornell voltage
Left ventricle hypertrophy
author_facet Jun Cui
Fang Bian
author_sort Jun Cui
title Current progress of the inflammasomes in aortic aneurysm and aortic dissection
title_short Current progress of the inflammasomes in aortic aneurysm and aortic dissection
title_full Current progress of the inflammasomes in aortic aneurysm and aortic dissection
title_fullStr Current progress of the inflammasomes in aortic aneurysm and aortic dissection
title_full_unstemmed Current progress of the inflammasomes in aortic aneurysm and aortic dissection
title_sort current progress of the inflammasomes in aortic aneurysm and aortic dissection
publisher Editorial Board of Journal of Hainan Medical University
series Journal of Hainan Medical University
issn 1007-1237
1007-1237
publishDate 2018-11-01
description Objective: ToAortic aneurysm (AA) is the permanent, irreversible, asymmetrical arterial dilation to at least 50% of the normal diameter. Aortic dissection (AD) may occur when the aorta enlarges to reach the tensile limit, which is the most lethal condition because of its rapid progression and high mortality. There is no doubt that inflammation is involved in the pathogenesis of AA and AD. Inflammasome, a large multi-protein complex in the cytosol regulating interleukin-1β (IL-1β) production, has critical roles on the pathogenesis of cardiovascular diseases. This review aims to summarize the current progress of the inflammasomes on AA/AD-related proteins and signal pathways to further explore the role of the inflammasomes in the progression of AA and AD.
topic Essential hypertension
ECG Cornell voltage
Left ventricle hypertrophy
url http://www.hnykdxxb.com/PDF/201811/21.pdf
work_keys_str_mv AT juncui currentprogressoftheinflammasomesinaorticaneurysmandaorticdissection
AT fangbian currentprogressoftheinflammasomesinaorticaneurysmandaorticdissection
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