Association of IgG1 Antibody Clearance with FcγRIIA Polymorphism and Platelet Count in Infliximab-Treated Patients

Association of IgG1 Antibody Clearance with FcγRIIA Polymorphism and Platelet Count in Infliximab-Treated Patients

The FcγRIIA/CD32A is mainly expressed on platelets, myeloid and several endothelial cells. Its affinity is considered insufficient for allowing significant binding of monomeric IgG, while its H131R polymorphism (histidine > arginine at position 131) influences affinity for multimeric IgG2. Platel...

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Bibliographic Details
Main Authors: Gilles Thibault, Gilles Paintaud, Hsueh Cheng Sung, Laurie Lajoie, Edouard Louis, the GETAID, Celine Desvignes, Hervé Watier, Valérie Gouilleux-Gruart, David Ternant
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
FcγRIIA
polymorphism
platelets
Fc–Fc receptor interaction
immunotherapy
monoclonal antibodies
Online Access:https://www.mdpi.com/1422-0067/22/11/6051

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