Formation of Microcages from a Collagen Mimetic Peptide via Metal-Ligand Interactions

Formation of Microcages from a Collagen Mimetic Peptide via Metal-Ligand Interactions

Here, the hierarchical assembly of a collagen mimetic peptide (CMP) displaying four bipyridine moieties is described. The CMP was capable of forming triple helices followed by self-assembly into disks and domes. Treatment of these disks and domes with metal ions such as Fe(II), Cu(II), Zn(II), Co(II...

Full description

Bibliographic Details
Main Authors: Jeremy Gleaton, Ryan W. Curtis, Jean Chmielewski
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
collagen mimetic peptide
hierarchical self-assembly
encapsulation
thermal release
Online Access:https://www.mdpi.com/1420-3049/26/16/4888
id doaj-5d32894cd6ed43be86063f3f918f1207
record_format Article
spelling doaj-5d32894cd6ed43be86063f3f918f12072021-08-26T14:07:32ZengMDPI AGMolecules1420-30492021-08-01264888488810.3390/molecules26164888Formation of Microcages from a Collagen Mimetic Peptide via Metal-Ligand InteractionsJeremy Gleaton0Ryan W. Curtis1Jean Chmielewski2Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USADepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USADepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USAHere, the hierarchical assembly of a collagen mimetic peptide (CMP) displaying four bipyridine moieties is described. The CMP was capable of forming triple helices followed by self-assembly into disks and domes. Treatment of these disks and domes with metal ions such as Fe(II), Cu(II), Zn(II), Co(II), and Ru(III) triggered the formation of microcages, and micron-sized cup-like structures. Mechanistic studies suggest that the formation of the microcages proceeds from the disks and domes in a metal-dependent fashion. Fluorescently-labeled dextrans were encapsulated within the cages and displayed a time-dependent release using thermal conditions.https://www.mdpi.com/1420-3049/26/16/4888collagen mimetic peptidehierarchical self-assemblyencapsulationthermal release
collection DOAJ
language English
format Article
sources DOAJ
author Jeremy Gleaton
Ryan W. Curtis
Jean Chmielewski
spellingShingle Jeremy Gleaton
Ryan W. Curtis
Jean Chmielewski
Formation of Microcages from a Collagen Mimetic Peptide via Metal-Ligand Interactions
Molecules
collagen mimetic peptide
hierarchical self-assembly
encapsulation
thermal release
author_facet Jeremy Gleaton
Ryan W. Curtis
Jean Chmielewski
author_sort Jeremy Gleaton
title Formation of Microcages from a Collagen Mimetic Peptide via Metal-Ligand Interactions
title_short Formation of Microcages from a Collagen Mimetic Peptide via Metal-Ligand Interactions
title_full Formation of Microcages from a Collagen Mimetic Peptide via Metal-Ligand Interactions
title_fullStr Formation of Microcages from a Collagen Mimetic Peptide via Metal-Ligand Interactions
title_full_unstemmed Formation of Microcages from a Collagen Mimetic Peptide via Metal-Ligand Interactions
title_sort formation of microcages from a collagen mimetic peptide via metal-ligand interactions
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2021-08-01
description Here, the hierarchical assembly of a collagen mimetic peptide (CMP) displaying four bipyridine moieties is described. The CMP was capable of forming triple helices followed by self-assembly into disks and domes. Treatment of these disks and domes with metal ions such as Fe(II), Cu(II), Zn(II), Co(II), and Ru(III) triggered the formation of microcages, and micron-sized cup-like structures. Mechanistic studies suggest that the formation of the microcages proceeds from the disks and domes in a metal-dependent fashion. Fluorescently-labeled dextrans were encapsulated within the cages and displayed a time-dependent release using thermal conditions.
topic collagen mimetic peptide
hierarchical self-assembly
encapsulation
thermal release
url https://www.mdpi.com/1420-3049/26/16/4888
work_keys_str_mv AT jeremygleaton formationofmicrocagesfromacollagenmimeticpeptideviametalligandinteractions
AT ryanwcurtis formationofmicrocagesfromacollagenmimeticpeptideviametalligandinteractions
AT jeanchmielewski formationofmicrocagesfromacollagenmimeticpeptideviametalligandinteractions
_version_ 1721191218987139072

Similar Items