Molecular Mechanisms of Bacterial Resistance to Metal and Metal Oxide Nanoparticles
The increase in bacterial resistance to one or several antibiotics has become a global health problem. Recently, nanomaterials have become a tool against multidrug-resistant bacteria. The metal and metal oxide nanoparticles are one of the most studied nanomaterials against multidrug-resistant bacter...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-06-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/20/11/2808 |
id |
doaj-5d3c15f770c4414882b5add5b13ed079 |
---|---|
record_format |
Article |
spelling |
doaj-5d3c15f770c4414882b5add5b13ed0792020-11-25T01:16:08ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-06-012011280810.3390/ijms20112808ijms20112808Molecular Mechanisms of Bacterial Resistance to Metal and Metal Oxide NanoparticlesNereyda Niño-Martínez0Marco Felipe Salas Orozco1Gabriel-Alejandro Martínez-Castañón2Fernando Torres Méndez3Facundo Ruiz4Facultad de Ciencias, Universidad Autónoma de San Luis Potosí, San Luis Potosí Cp 78210, MexicoFacultad de Estomatología, Universidad Autónoma de San Luis Potosí, San Luis Potosí Cp 78210, MexicoFacultad de Estomatología, Universidad Autónoma de San Luis Potosí, San Luis Potosí Cp 78210, MexicoFacultad de Estomatología, Universidad Autónoma de San Luis Potosí, San Luis Potosí Cp 78210, MexicoFacultad de Ciencias, Universidad Autónoma de San Luis Potosí, San Luis Potosí Cp 78210, MexicoThe increase in bacterial resistance to one or several antibiotics has become a global health problem. Recently, nanomaterials have become a tool against multidrug-resistant bacteria. The metal and metal oxide nanoparticles are one of the most studied nanomaterials against multidrug-resistant bacteria. Several in vitro studies report that metal nanoparticles have antimicrobial properties against a broad spectrum of bacterial species. However, until recently, the bacterial resistance mechanisms to the bactericidal action of the nanoparticles had not been investigated. Some of the recently reported resistance mechanisms include electrostatic repulsion, ion efflux pumps, expression of extracellular matrices, and the adaptation of biofilms and mutations. The objective of this review is to summarize the recent findings regarding the mechanisms used by bacteria to counteract the antimicrobial effects of nanoparticles.https://www.mdpi.com/1422-0067/20/11/2808bacteriaresistancenanoparticles |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nereyda Niño-Martínez Marco Felipe Salas Orozco Gabriel-Alejandro Martínez-Castañón Fernando Torres Méndez Facundo Ruiz |
spellingShingle |
Nereyda Niño-Martínez Marco Felipe Salas Orozco Gabriel-Alejandro Martínez-Castañón Fernando Torres Méndez Facundo Ruiz Molecular Mechanisms of Bacterial Resistance to Metal and Metal Oxide Nanoparticles International Journal of Molecular Sciences bacteria resistance nanoparticles |
author_facet |
Nereyda Niño-Martínez Marco Felipe Salas Orozco Gabriel-Alejandro Martínez-Castañón Fernando Torres Méndez Facundo Ruiz |
author_sort |
Nereyda Niño-Martínez |
title |
Molecular Mechanisms of Bacterial Resistance to Metal and Metal Oxide Nanoparticles |
title_short |
Molecular Mechanisms of Bacterial Resistance to Metal and Metal Oxide Nanoparticles |
title_full |
Molecular Mechanisms of Bacterial Resistance to Metal and Metal Oxide Nanoparticles |
title_fullStr |
Molecular Mechanisms of Bacterial Resistance to Metal and Metal Oxide Nanoparticles |
title_full_unstemmed |
Molecular Mechanisms of Bacterial Resistance to Metal and Metal Oxide Nanoparticles |
title_sort |
molecular mechanisms of bacterial resistance to metal and metal oxide nanoparticles |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-06-01 |
description |
The increase in bacterial resistance to one or several antibiotics has become a global health problem. Recently, nanomaterials have become a tool against multidrug-resistant bacteria. The metal and metal oxide nanoparticles are one of the most studied nanomaterials against multidrug-resistant bacteria. Several in vitro studies report that metal nanoparticles have antimicrobial properties against a broad spectrum of bacterial species. However, until recently, the bacterial resistance mechanisms to the bactericidal action of the nanoparticles had not been investigated. Some of the recently reported resistance mechanisms include electrostatic repulsion, ion efflux pumps, expression of extracellular matrices, and the adaptation of biofilms and mutations. The objective of this review is to summarize the recent findings regarding the mechanisms used by bacteria to counteract the antimicrobial effects of nanoparticles. |
topic |
bacteria resistance nanoparticles |
url |
https://www.mdpi.com/1422-0067/20/11/2808 |
work_keys_str_mv |
AT nereydaninomartinez molecularmechanismsofbacterialresistancetometalandmetaloxidenanoparticles AT marcofelipesalasorozco molecularmechanismsofbacterialresistancetometalandmetaloxidenanoparticles AT gabrielalejandromartinezcastanon molecularmechanismsofbacterialresistancetometalandmetaloxidenanoparticles AT fernandotorresmendez molecularmechanismsofbacterialresistancetometalandmetaloxidenanoparticles AT facundoruiz molecularmechanismsofbacterialresistancetometalandmetaloxidenanoparticles |
_version_ |
1725151105881473024 |