Concurrent Cognitive Control Training Augments the Antidepressant Efficacy of tDCS: A Pilot Study
Background: Major depressive disorder (MDD) is frequently associated with underactivity of the dorsolateral prefrontal cortex (DLPFC) which has led to this brain region being identified as an important target for the development of neurobiological treatments. Transcranial direct current stimulation...
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doaj-5d448ea5a61f4a7299e141fc469b03b02021-03-18T04:37:17ZengElsevierBrain Stimulation1935-861X2014-03-0172325331Concurrent Cognitive Control Training Augments the Antidepressant Efficacy of tDCS: A Pilot StudyR.A. Segrave0S. Arnold1K. Hoy2P.B. Fitzgerald3Corresponding author. Tel.: +61 3 9076 5030.; Monash University, Central Clinical School, Monash Alfred Psychiatry Research Centre, Level 4, 607 St Kilda Rd., Prahran, VIC 3004, AustraliaMonash University, Central Clinical School, Monash Alfred Psychiatry Research Centre, Level 4, 607 St Kilda Rd., Prahran, VIC 3004, AustraliaMonash University, Central Clinical School, Monash Alfred Psychiatry Research Centre, Level 4, 607 St Kilda Rd., Prahran, VIC 3004, AustraliaMonash University, Central Clinical School, Monash Alfred Psychiatry Research Centre, Level 4, 607 St Kilda Rd., Prahran, VIC 3004, AustraliaBackground: Major depressive disorder (MDD) is frequently associated with underactivity of the dorsolateral prefrontal cortex (DLPFC) which has led to this brain region being identified as an important target for the development of neurobiological treatments. Transcranial direct current stimulation (tDCS) administered to the DLPFC has antidepressant efficacy, however the magnitude of antidepressant outcomes are limited. Concurrent cognitive activity has been shown to enhance tDCS induced stimulation effects. Cognitive control training (CCT) is a new cognitive therapy for MDD that aims to enhance DLPFC activity via behavioral methods. Hypothesis: We tested the hypothesis that co-administration of DLPFC tDCS and CCT would result in a greater reduction in depressive symptomology than administration of tDCS or CCT alone. Methods: 27 adult participants with MDD were randomized into a three-arm sham-controlled between-groups pilot study comparing the efficacy of 2 mA tDCS + CCT, sham tDCS + CCT and sham CCT + 2 mA tDCS (5 sessions administered on consecutive working days). Blinded assessments of depression severity and cognitive control were conducted at baseline, end of treatment and a three week follow up review. Results: All three treatment conditions were associated with a reduction in depression severity at the end of five treatment sessions. However, only administration of tDCS + CCT resulted in sustained antidepressant response at follow up, the magnitude of which was greater than that observed immediately following conclusion of the treatment course. Conclusions: The results provide preliminary evidence that concurrent CCT enhances antidepressant outcomes from tDCS. In the current sample, participants receiving concurrent tDCS and CCT continued to improve following cessation of treatment. The clinical superiority of a combined therapeutic approach was apparent even in a small sample and following a relatively short treatment course.http://www.sciencedirect.com/science/article/pii/S1935861X13003999DepressionTranscranial direct current stimulationCognitive trainingCognitive controlDorsolateral prefrontal cortex |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
R.A. Segrave S. Arnold K. Hoy P.B. Fitzgerald |
spellingShingle |
R.A. Segrave S. Arnold K. Hoy P.B. Fitzgerald Concurrent Cognitive Control Training Augments the Antidepressant Efficacy of tDCS: A Pilot Study Brain Stimulation Depression Transcranial direct current stimulation Cognitive training Cognitive control Dorsolateral prefrontal cortex |
author_facet |
R.A. Segrave S. Arnold K. Hoy P.B. Fitzgerald |
author_sort |
R.A. Segrave |
title |
Concurrent Cognitive Control Training Augments the Antidepressant Efficacy of tDCS: A Pilot Study |
title_short |
Concurrent Cognitive Control Training Augments the Antidepressant Efficacy of tDCS: A Pilot Study |
title_full |
Concurrent Cognitive Control Training Augments the Antidepressant Efficacy of tDCS: A Pilot Study |
title_fullStr |
Concurrent Cognitive Control Training Augments the Antidepressant Efficacy of tDCS: A Pilot Study |
title_full_unstemmed |
Concurrent Cognitive Control Training Augments the Antidepressant Efficacy of tDCS: A Pilot Study |
title_sort |
concurrent cognitive control training augments the antidepressant efficacy of tdcs: a pilot study |
publisher |
Elsevier |
series |
Brain Stimulation |
issn |
1935-861X |
publishDate |
2014-03-01 |
description |
Background: Major depressive disorder (MDD) is frequently associated with underactivity of the dorsolateral prefrontal cortex (DLPFC) which has led to this brain region being identified as an important target for the development of neurobiological treatments. Transcranial direct current stimulation (tDCS) administered to the DLPFC has antidepressant efficacy, however the magnitude of antidepressant outcomes are limited. Concurrent cognitive activity has been shown to enhance tDCS induced stimulation effects. Cognitive control training (CCT) is a new cognitive therapy for MDD that aims to enhance DLPFC activity via behavioral methods. Hypothesis: We tested the hypothesis that co-administration of DLPFC tDCS and CCT would result in a greater reduction in depressive symptomology than administration of tDCS or CCT alone. Methods: 27 adult participants with MDD were randomized into a three-arm sham-controlled between-groups pilot study comparing the efficacy of 2 mA tDCS + CCT, sham tDCS + CCT and sham CCT + 2 mA tDCS (5 sessions administered on consecutive working days). Blinded assessments of depression severity and cognitive control were conducted at baseline, end of treatment and a three week follow up review. Results: All three treatment conditions were associated with a reduction in depression severity at the end of five treatment sessions. However, only administration of tDCS + CCT resulted in sustained antidepressant response at follow up, the magnitude of which was greater than that observed immediately following conclusion of the treatment course. Conclusions: The results provide preliminary evidence that concurrent CCT enhances antidepressant outcomes from tDCS. In the current sample, participants receiving concurrent tDCS and CCT continued to improve following cessation of treatment. The clinical superiority of a combined therapeutic approach was apparent even in a small sample and following a relatively short treatment course. |
topic |
Depression Transcranial direct current stimulation Cognitive training Cognitive control Dorsolateral prefrontal cortex |
url |
http://www.sciencedirect.com/science/article/pii/S1935861X13003999 |
work_keys_str_mv |
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