Crucial Development: Criticality Is Important to Cell-to-Cell Communication and Information Transfer in Living Systems

• Main Authors: Ione Hunt von Herbing, Lucio Tonello, Maurizio Benfatto, April Pease, Paolo Grigolini
• Format: Article
• Language: English
• Published: MDPI AG 2021-08-01
• Series: Entropy
• Subjects: complexity; non-crucial events; crucial events; FBM; memory; embryos
• Online Access: https://www.mdpi.com/1099-4300/23/9/1141

In the fourth paper of this Special Issue, we bridge the theoretical debate on the role of memory and criticality discussed in the three earlier manuscripts, with a review of key concepts in biology and focus on cell-to-cell communication in organismal development. While all living organisms are dynamic complex networks of organization and disorder, most studies in biology have used energy and biochemical exchange to explain cell differentiation without considering the importance of information (entropy) transfer. While all complex networks are mixtures of patterns of complexity (non-crucial and crucial events), it is the crucial events that determine the efficiency of information transfer, especially during key transitions, such as in embryogenesis. With increasing multicellularity, emergent relationships from cell-to-cell communication create reaction–diffusion exchanges of different concentrations of biochemicals or morphogenetic gradients resulting in differential gene expression. We suggest that in conjunction with morphogenetic gradients, there exist gradients of information transfer creating cybernetic loops of stability and disorder, setting the stage for adaptive capability. We specifically reference results from the second paper in this Special Issue, which correlated biophotons with lentil seed germination to show that phase transitions accompany changes in complexity patterns during development. Criticality, therefore, appears to be an important factor in the transmission, transfer and coding of information for complex adaptive system development.