lncRNA RMRP predicts poor prognosis and mediates tumor progression of esophageal squamous cell carcinoma by regulating miR-613/ neuropilin 2 (NRP2) axis
The RNA component of mitochondrial RNA processing endoribonuclease (RMRP) has been reported to play a role in the development of various human diseases. The clinical significance and biological function of RMRP in the progression of esophageal squamous cell carcinoma (ESCC) and the potential mechani...
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Online Access: | http://dx.doi.org/10.1080/21655979.2021.1974656 |
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doaj-5d52d56041de48589e5456010f4fe5572021-09-20T13:17:22ZengTaylor & Francis GroupBioengineered2165-59792165-59872021-01-011216913692210.1080/21655979.2021.19746561974656lncRNA RMRP predicts poor prognosis and mediates tumor progression of esophageal squamous cell carcinoma by regulating miR-613/ neuropilin 2 (NRP2) axisZhen Xie0Shuai Liu1Shicheng Chu2Yiqun Liu3Bingtao Huang4Qingguang Zhang5Binzhou Medical University HospitalBinzhou Medical University HospitalBinzhou Medical University HospitalBinzhou Medical University HospitalBinzhou Medical University HospitalBinzhou Medical University HospitalThe RNA component of mitochondrial RNA processing endoribonuclease (RMRP) has been reported to play a role in the development of various human diseases. The clinical significance and biological function of RMRP in the progression of esophageal squamous cell carcinoma (ESCC) and the potential mechanism were investigated in this study.A total of 118 ESCC patients were included in this study. The expression of RMRP in ESCC was analyzed with the help of the polymerase chain reaction. The cell counting kit 8 assay was employed to evaluate the role of RMRP in cell proliferation, and its functions in cell migration and invasion were assessed by the Transwell assays. Meanwhile, the clinical significance of RMRP in ESCC was estimated with Kaplan-Meier and Cox regression analysis.RMRP was significantly upregulated in ESCC, which was associated with the lymph node metastasis status, the TNM stage of patients, and a poor outcome of ESCC patients. Moreover, RMRP promoted the proliferation, migration, and invasion of ESCC cells via regulating miR-613/NRP2.RMRP was involved in the progression of ESCC through regulating the miR-613/NRP2 axis, which provides a potential target for the treatment of ESCC.http://dx.doi.org/10.1080/21655979.2021.1974656lncrna rmrpesophageal squamous cell carcinomaprognosisprogressionproliferationmigrationinvasion |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhen Xie Shuai Liu Shicheng Chu Yiqun Liu Bingtao Huang Qingguang Zhang |
spellingShingle |
Zhen Xie Shuai Liu Shicheng Chu Yiqun Liu Bingtao Huang Qingguang Zhang lncRNA RMRP predicts poor prognosis and mediates tumor progression of esophageal squamous cell carcinoma by regulating miR-613/ neuropilin 2 (NRP2) axis Bioengineered lncrna rmrp esophageal squamous cell carcinoma prognosis progression proliferation migration invasion |
author_facet |
Zhen Xie Shuai Liu Shicheng Chu Yiqun Liu Bingtao Huang Qingguang Zhang |
author_sort |
Zhen Xie |
title |
lncRNA RMRP predicts poor prognosis and mediates tumor progression of esophageal squamous cell carcinoma by regulating miR-613/ neuropilin 2 (NRP2) axis |
title_short |
lncRNA RMRP predicts poor prognosis and mediates tumor progression of esophageal squamous cell carcinoma by regulating miR-613/ neuropilin 2 (NRP2) axis |
title_full |
lncRNA RMRP predicts poor prognosis and mediates tumor progression of esophageal squamous cell carcinoma by regulating miR-613/ neuropilin 2 (NRP2) axis |
title_fullStr |
lncRNA RMRP predicts poor prognosis and mediates tumor progression of esophageal squamous cell carcinoma by regulating miR-613/ neuropilin 2 (NRP2) axis |
title_full_unstemmed |
lncRNA RMRP predicts poor prognosis and mediates tumor progression of esophageal squamous cell carcinoma by regulating miR-613/ neuropilin 2 (NRP2) axis |
title_sort |
lncrna rmrp predicts poor prognosis and mediates tumor progression of esophageal squamous cell carcinoma by regulating mir-613/ neuropilin 2 (nrp2) axis |
publisher |
Taylor & Francis Group |
series |
Bioengineered |
issn |
2165-5979 2165-5987 |
publishDate |
2021-01-01 |
description |
The RNA component of mitochondrial RNA processing endoribonuclease (RMRP) has been reported to play a role in the development of various human diseases. The clinical significance and biological function of RMRP in the progression of esophageal squamous cell carcinoma (ESCC) and the potential mechanism were investigated in this study.A total of 118 ESCC patients were included in this study. The expression of RMRP in ESCC was analyzed with the help of the polymerase chain reaction. The cell counting kit 8 assay was employed to evaluate the role of RMRP in cell proliferation, and its functions in cell migration and invasion were assessed by the Transwell assays. Meanwhile, the clinical significance of RMRP in ESCC was estimated with Kaplan-Meier and Cox regression analysis.RMRP was significantly upregulated in ESCC, which was associated with the lymph node metastasis status, the TNM stage of patients, and a poor outcome of ESCC patients. Moreover, RMRP promoted the proliferation, migration, and invasion of ESCC cells via regulating miR-613/NRP2.RMRP was involved in the progression of ESCC through regulating the miR-613/NRP2 axis, which provides a potential target for the treatment of ESCC. |
topic |
lncrna rmrp esophageal squamous cell carcinoma prognosis progression proliferation migration invasion |
url |
http://dx.doi.org/10.1080/21655979.2021.1974656 |
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