Pre-Clinical Tests of an Integrated CMOS Biomolecular Sensor for Cardiac Diseases Diagnosis
Coronary artery disease and its related complications pose great threats to human health. In this work, we aim to clinically evaluate a CMOS field-effect biomolecular sensor for cardiac biomarkers, cardiac-specific troponin-I (cTnI), N-terminal prohormone brain natriuretic peptide (NT-proBNP), and i...
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MDPI AG
2017-11-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/17/12/2733 |
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doaj-5d5abfcad6cb400c94f4353a8e26d20f2020-11-25T00:56:09ZengMDPI AGSensors1424-82202017-11-011712273310.3390/s17122733s17122733Pre-Clinical Tests of an Integrated CMOS Biomolecular Sensor for Cardiac Diseases DiagnosisJen-Kuang Lee0I-Shun Wang1Chi-Hsien Huang2Yih-Fan Chen3Nien-Tsu Huang4Chih-Ting Lin5Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 10617, TaiwanGraduate Institute of Electronics Engineering, National Taiwan University, Taipei 10617, TaiwanDepartment of Materials Engineering, Ming Chi University of Technology, New Taipei 24301, TaiwanInsisute of Biophotonics, National Yang-Ming University, Taipei 11221, TaiwanGraduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 10617, TaiwanGraduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 10617, TaiwanCoronary artery disease and its related complications pose great threats to human health. In this work, we aim to clinically evaluate a CMOS field-effect biomolecular sensor for cardiac biomarkers, cardiac-specific troponin-I (cTnI), N-terminal prohormone brain natriuretic peptide (NT-proBNP), and interleukin-6 (IL-6). The CMOS biosensor is implemented via a standard commercialized 0.35 μm CMOS process. To validate the sensing characteristics, in buffer conditions, the developed CMOS biosensor has identified the detection limits of IL-6, cTnI, and NT-proBNP as being 45 pM, 32 pM, and 32 pM, respectively. In clinical serum conditions, furthermore, the developed CMOS biosensor performs a good correlation with an enzyme-linked immuno-sorbent assay (ELISA) obtained from a hospital central laboratory. Based on this work, the CMOS field-effect biosensor poses good potential for accomplishing the needs of a point-of-care testing (POCT) system for heart disease diagnosis.https://www.mdpi.com/1424-8220/17/12/2733CMOS biosensorfield-effect biosensorheart diseasetroponin-IN-terminal prohormone brain natriuretic peptideinterleukin-6 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jen-Kuang Lee I-Shun Wang Chi-Hsien Huang Yih-Fan Chen Nien-Tsu Huang Chih-Ting Lin |
| spellingShingle |
Jen-Kuang Lee I-Shun Wang Chi-Hsien Huang Yih-Fan Chen Nien-Tsu Huang Chih-Ting Lin Pre-Clinical Tests of an Integrated CMOS Biomolecular Sensor for Cardiac Diseases Diagnosis Sensors CMOS biosensor field-effect biosensor heart disease troponin-I N-terminal prohormone brain natriuretic peptide interleukin-6 |
| author_facet |
Jen-Kuang Lee I-Shun Wang Chi-Hsien Huang Yih-Fan Chen Nien-Tsu Huang Chih-Ting Lin |
| author_sort |
Jen-Kuang Lee |
| title |
Pre-Clinical Tests of an Integrated CMOS Biomolecular Sensor for Cardiac Diseases Diagnosis |
| title_short |
Pre-Clinical Tests of an Integrated CMOS Biomolecular Sensor for Cardiac Diseases Diagnosis |
| title_full |
Pre-Clinical Tests of an Integrated CMOS Biomolecular Sensor for Cardiac Diseases Diagnosis |
| title_fullStr |
Pre-Clinical Tests of an Integrated CMOS Biomolecular Sensor for Cardiac Diseases Diagnosis |
| title_full_unstemmed |
Pre-Clinical Tests of an Integrated CMOS Biomolecular Sensor for Cardiac Diseases Diagnosis |
| title_sort |
pre-clinical tests of an integrated cmos biomolecular sensor for cardiac diseases diagnosis |
| publisher |
MDPI AG |
| series |
Sensors |
| issn |
1424-8220 |
| publishDate |
2017-11-01 |
| description |
Coronary artery disease and its related complications pose great threats to human health. In this work, we aim to clinically evaluate a CMOS field-effect biomolecular sensor for cardiac biomarkers, cardiac-specific troponin-I (cTnI), N-terminal prohormone brain natriuretic peptide (NT-proBNP), and interleukin-6 (IL-6). The CMOS biosensor is implemented via a standard commercialized 0.35 μm CMOS process. To validate the sensing characteristics, in buffer conditions, the developed CMOS biosensor has identified the detection limits of IL-6, cTnI, and NT-proBNP as being 45 pM, 32 pM, and 32 pM, respectively. In clinical serum conditions, furthermore, the developed CMOS biosensor performs a good correlation with an enzyme-linked immuno-sorbent assay (ELISA) obtained from a hospital central laboratory. Based on this work, the CMOS field-effect biosensor poses good potential for accomplishing the needs of a point-of-care testing (POCT) system for heart disease diagnosis. |
| topic |
CMOS biosensor field-effect biosensor heart disease troponin-I N-terminal prohormone brain natriuretic peptide interleukin-6 |
| url |
https://www.mdpi.com/1424-8220/17/12/2733 |
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