Heart Rate Asymmetry Analysis During Head-Up Tilt Test in Healthy Men
The purpose of this study is to assess the cardiovascular system response to orthostatic stress in a group of 133 healthy men using heart rate asymmetry (HRA) methods. HRA is a feature of variability in human heart rate which is dependent upon external and internal body conditions. The initial phase...
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doaj-5d60790bc9ba470983a736a75f27d7562021-04-13T06:28:38ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-04-011210.3389/fphys.2021.657902657902Heart Rate Asymmetry Analysis During Head-Up Tilt Test in Healthy MenRafał Pawłowski0Katarzyna Buszko1Julia L. Newton2Sławomir Kujawski3Paweł Zalewski4Department of Biostatistics and Theory of Biomedical Systems, Faculty of Pharmacy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, PolandDepartment of Biostatistics and Theory of Biomedical Systems, Faculty of Pharmacy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, PolandPopulation Health Sciences Institute, The Medical School, Newcastle University, Newcastle upon Tyne, United KingdomDepartment of Hygiene, Epidemiology, Ergonomics and Postgraduate Education, Faculty of Health Sciences, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, PolandDepartment of Hygiene, Epidemiology, Ergonomics and Postgraduate Education, Faculty of Health Sciences, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, PolandThe purpose of this study is to assess the cardiovascular system response to orthostatic stress in a group of 133 healthy men using heart rate asymmetry (HRA) methods. HRA is a feature of variability in human heart rate which is dependent upon external and internal body conditions. The initial phases of head-up tilt test (HUTT), namely, supine and tilt, were chosen as the external body affecting factors. Various calculation methods of HRA, such as Porta’s index (PI), Guzik’s index (GI), and its variance based components, were used to assess the heart rate variability (HRV) and its asymmetry. We compared 5-min ECG recordings from both supine and tilt phases of HUT test. Short-term HRA was observed in 54.1% of men in supine phase and 65.4% of men in tilt phase. The study revealed significant increase of GI (from 0.50 to 0.52, p < 0.001) in the tilt phase as well as significant changes in HRV descriptors between HUTT phases. Our results showed that the variability of human heart rate and its asymmetry are sensitive to orthostatic stress. The study of short-term HRA is a potential additional tool to increase sensitivity in conditions where HUTT is a diagnostic tool, such as vasovagal syncope.https://www.frontiersin.org/articles/10.3389/fphys.2021.657902/fullheart rate asymmetryhead-up tilt testheart rate variabilityPoincaré plotGuzik’s indexPorta’s index |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rafał Pawłowski Katarzyna Buszko Julia L. Newton Sławomir Kujawski Paweł Zalewski |
spellingShingle |
Rafał Pawłowski Katarzyna Buszko Julia L. Newton Sławomir Kujawski Paweł Zalewski Heart Rate Asymmetry Analysis During Head-Up Tilt Test in Healthy Men Frontiers in Physiology heart rate asymmetry head-up tilt test heart rate variability Poincaré plot Guzik’s index Porta’s index |
author_facet |
Rafał Pawłowski Katarzyna Buszko Julia L. Newton Sławomir Kujawski Paweł Zalewski |
author_sort |
Rafał Pawłowski |
title |
Heart Rate Asymmetry Analysis During Head-Up Tilt Test in Healthy Men |
title_short |
Heart Rate Asymmetry Analysis During Head-Up Tilt Test in Healthy Men |
title_full |
Heart Rate Asymmetry Analysis During Head-Up Tilt Test in Healthy Men |
title_fullStr |
Heart Rate Asymmetry Analysis During Head-Up Tilt Test in Healthy Men |
title_full_unstemmed |
Heart Rate Asymmetry Analysis During Head-Up Tilt Test in Healthy Men |
title_sort |
heart rate asymmetry analysis during head-up tilt test in healthy men |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2021-04-01 |
description |
The purpose of this study is to assess the cardiovascular system response to orthostatic stress in a group of 133 healthy men using heart rate asymmetry (HRA) methods. HRA is a feature of variability in human heart rate which is dependent upon external and internal body conditions. The initial phases of head-up tilt test (HUTT), namely, supine and tilt, were chosen as the external body affecting factors. Various calculation methods of HRA, such as Porta’s index (PI), Guzik’s index (GI), and its variance based components, were used to assess the heart rate variability (HRV) and its asymmetry. We compared 5-min ECG recordings from both supine and tilt phases of HUT test. Short-term HRA was observed in 54.1% of men in supine phase and 65.4% of men in tilt phase. The study revealed significant increase of GI (from 0.50 to 0.52, p < 0.001) in the tilt phase as well as significant changes in HRV descriptors between HUTT phases. Our results showed that the variability of human heart rate and its asymmetry are sensitive to orthostatic stress. The study of short-term HRA is a potential additional tool to increase sensitivity in conditions where HUTT is a diagnostic tool, such as vasovagal syncope. |
topic |
heart rate asymmetry head-up tilt test heart rate variability Poincaré plot Guzik’s index Porta’s index |
url |
https://www.frontiersin.org/articles/10.3389/fphys.2021.657902/full |
work_keys_str_mv |
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