Insulin Secretory Defect and Insulin Resistance in Isolated Impaired Fasting Glucose and Isolated Impaired Glucose Tolerance
Objective. To investigate the characteristics of isolated impaired glucose tolerance (IGT) and isolated impaired fasting glucose (IFG), we analyzed the factors responsible for elevation of 2-hour postchallenge plasma glucose (2 h PG) and fasting plasma glucose (FPG) levels. Methods. We investigated...
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2016-01-01
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Series: | Journal of Diabetes Research |
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doaj-5d6222b1e846409fb55185d0aa936a582020-11-24T21:42:15ZengHindawi LimitedJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/12986011298601Insulin Secretory Defect and Insulin Resistance in Isolated Impaired Fasting Glucose and Isolated Impaired Glucose ToleranceSae Aoyama-Sasabe0Mitsuo Fukushima1Xin Xin2Ataru Taniguchi3Yoshikatsu Nakai4Rie Mitsui5Yoshitaka Takahashi6Hideaki Tsuji7Daisuke Yabe8Koichiro Yasuda9Takeshi Kurose10Nobuya Inagaki11Yutaka Seino12Division of Clinical Nutrition and Internal Medicine, Okayama Prefectural University, Okayama 719-1197, JapanDivision of Clinical Nutrition and Internal Medicine, Okayama Prefectural University, Okayama 719-1197, JapanFaculty of Computer Science and Systems Engineering, Okayama Prefectural University, Okayama 719-1197, JapanDivision of Diabetes and Endocrinology, Kyoto Preventive Medical Center, Kyoto 604-8491, JapanKyoto Institute of Health Science, Kyoto 604-0845, JapanCenter for Preventive Medicine, St. Luke’s International Hospital, Tokyo 104-6591, JapanFaculty of Health and Welfare Science, Okayama Prefectural University, Okayama 719-1197, JapanFaculty of Health and Welfare Science, Okayama Prefectural University, Okayama 719-1197, JapanCenter for Diabetes, Endocrinology and Metabolism, Kansai Electric Power Hospital, Osaka 553-0003, JapanDepartment of Diabetes and Endocrinology, Saiseikai Noe Hospital, Osaka 536-0001, JapanCenter for Diabetes, Endocrinology and Metabolism, Kansai Electric Power Hospital, Osaka 553-0003, JapanDepartment of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, JapanCenter for Diabetes, Endocrinology and Metabolism, Kansai Electric Power Hospital, Osaka 553-0003, JapanObjective. To investigate the characteristics of isolated impaired glucose tolerance (IGT) and isolated impaired fasting glucose (IFG), we analyzed the factors responsible for elevation of 2-hour postchallenge plasma glucose (2 h PG) and fasting plasma glucose (FPG) levels. Methods. We investigated the relationship between 2 h PG and FPG levels who underwent 75 g OGTT in 5620 Japanese subjects at initial examination for medical check-up. We compared clinical characteristics between isolated IGT and isolated IFG and analyzed the relationships of 2 h PG and FPG with clinical characteristics, the indices of insulin secretory capacity, and insulin sensitivity. Results. In a comparison between isolated IGT and isolated IFG, insulinogenic index was lower in isolated IGT than that of isolated IFG (0.43 ± 0.34 versus 0.50 ± 0.47, resp.; p<0.01). ISI composite was lower in isolated IFG than that of isolated IGT (6.87 ± 3.38 versus 7.98 ± 4.03, resp.; p<0.0001). In isolated IGT group, insulinogenic index showed a significant correlation with 2 h PG (r=-0.245, p<0.0001) and had the strongest correlation with 2 h PG (β=-0.290). In isolated IFG group, ISI composite showed a significant correlation with FPG (r=-0.162, p<0.0001) and had the strongest correlation with FPG (β=-0.214). Conclusions. We have elucidated that decreased early-phase insulin secretion is the most important factor responsible for elevation of 2 h PG levels in isolated IGT subjects, and decreased insulin sensitivity is the most important factor responsible for elevation of FPG levels in isolated IFG subjects.http://dx.doi.org/10.1155/2016/1298601 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sae Aoyama-Sasabe Mitsuo Fukushima Xin Xin Ataru Taniguchi Yoshikatsu Nakai Rie Mitsui Yoshitaka Takahashi Hideaki Tsuji Daisuke Yabe Koichiro Yasuda Takeshi Kurose Nobuya Inagaki Yutaka Seino |
spellingShingle |
Sae Aoyama-Sasabe Mitsuo Fukushima Xin Xin Ataru Taniguchi Yoshikatsu Nakai Rie Mitsui Yoshitaka Takahashi Hideaki Tsuji Daisuke Yabe Koichiro Yasuda Takeshi Kurose Nobuya Inagaki Yutaka Seino Insulin Secretory Defect and Insulin Resistance in Isolated Impaired Fasting Glucose and Isolated Impaired Glucose Tolerance Journal of Diabetes Research |
author_facet |
Sae Aoyama-Sasabe Mitsuo Fukushima Xin Xin Ataru Taniguchi Yoshikatsu Nakai Rie Mitsui Yoshitaka Takahashi Hideaki Tsuji Daisuke Yabe Koichiro Yasuda Takeshi Kurose Nobuya Inagaki Yutaka Seino |
author_sort |
Sae Aoyama-Sasabe |
title |
Insulin Secretory Defect and Insulin Resistance in Isolated Impaired Fasting Glucose and Isolated Impaired Glucose Tolerance |
title_short |
Insulin Secretory Defect and Insulin Resistance in Isolated Impaired Fasting Glucose and Isolated Impaired Glucose Tolerance |
title_full |
Insulin Secretory Defect and Insulin Resistance in Isolated Impaired Fasting Glucose and Isolated Impaired Glucose Tolerance |
title_fullStr |
Insulin Secretory Defect and Insulin Resistance in Isolated Impaired Fasting Glucose and Isolated Impaired Glucose Tolerance |
title_full_unstemmed |
Insulin Secretory Defect and Insulin Resistance in Isolated Impaired Fasting Glucose and Isolated Impaired Glucose Tolerance |
title_sort |
insulin secretory defect and insulin resistance in isolated impaired fasting glucose and isolated impaired glucose tolerance |
publisher |
Hindawi Limited |
series |
Journal of Diabetes Research |
issn |
2314-6745 2314-6753 |
publishDate |
2016-01-01 |
description |
Objective. To investigate the characteristics of isolated impaired glucose tolerance (IGT) and isolated impaired fasting glucose (IFG), we analyzed the factors responsible for elevation of 2-hour postchallenge plasma glucose (2 h PG) and fasting plasma glucose (FPG) levels. Methods. We investigated the relationship between 2 h PG and FPG levels who underwent 75 g OGTT in 5620 Japanese subjects at initial examination for medical check-up. We compared clinical characteristics between isolated IGT and isolated IFG and analyzed the relationships of 2 h PG and FPG with clinical characteristics, the indices of insulin secretory capacity, and insulin sensitivity. Results. In a comparison between isolated IGT and isolated IFG, insulinogenic index was lower in isolated IGT than that of isolated IFG (0.43 ± 0.34 versus 0.50 ± 0.47, resp.; p<0.01). ISI composite was lower in isolated IFG than that of isolated IGT (6.87 ± 3.38 versus 7.98 ± 4.03, resp.; p<0.0001). In isolated IGT group, insulinogenic index showed a significant correlation with 2 h PG (r=-0.245, p<0.0001) and had the strongest correlation with 2 h PG (β=-0.290). In isolated IFG group, ISI composite showed a significant correlation with FPG (r=-0.162, p<0.0001) and had the strongest correlation with FPG (β=-0.214). Conclusions. We have elucidated that decreased early-phase insulin secretion is the most important factor responsible for elevation of 2 h PG levels in isolated IGT subjects, and decreased insulin sensitivity is the most important factor responsible for elevation of FPG levels in isolated IFG subjects. |
url |
http://dx.doi.org/10.1155/2016/1298601 |
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