Topical Nano and Microemulsions for Skin Delivery
Nanosystems such as microemulsions (ME) and nanoemulsions (NE) offer considerable opportunities for targeted drug delivery to and via the skin. ME and NE are stable colloidal systems composed of oil and water, stabilised by a mixture of surfactants and cosurfactants, that have received particular in...
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doaj-5d6306ed13e04679b1e4ee6cb72554e92020-11-24T22:10:56ZengMDPI AGPharmaceutics1999-49232017-09-01943710.3390/pharmaceutics9040037pharmaceutics9040037Topical Nano and Microemulsions for Skin DeliveryChristofori M. R. R. Nastiti0Thellie Ponto1Eman Abd2Jeffrey E. Grice3Heather A. E. Benson4Michael S. Roberts5School of Pharmacy, Curtin Health Innovation Research Institute, Curtin University, G.P.O. Box U1987, Perth, WA 6845, AustraliaSchool of Pharmacy, Curtin Health Innovation Research Institute, Curtin University, G.P.O. Box U1987, Perth, WA 6845, AustraliaTherapeutics Research Centre, The University of Queensland Diamentina Institute, Faculty of Medicine, Translational Research Institute, Woolloongabba, QLD 4102, AustraliaTherapeutics Research Centre, The University of Queensland Diamentina Institute, Faculty of Medicine, Translational Research Institute, Woolloongabba, QLD 4102, AustraliaSchool of Pharmacy, Curtin Health Innovation Research Institute, Curtin University, G.P.O. Box U1987, Perth, WA 6845, AustraliaTherapeutics Research Centre, The University of Queensland Diamentina Institute, Faculty of Medicine, Translational Research Institute, Woolloongabba, QLD 4102, AustraliaNanosystems such as microemulsions (ME) and nanoemulsions (NE) offer considerable opportunities for targeted drug delivery to and via the skin. ME and NE are stable colloidal systems composed of oil and water, stabilised by a mixture of surfactants and cosurfactants, that have received particular interest as topical skin delivery systems. There is considerable scope to manipulate the formulation components and characteristics to achieve optimal bioavailability and minimal skin irritancy. This includes the incorporation of established chemical penetration enhancers to fluidize the stratum corneum lipid bilayers, thus reducing the primary skin barrier and increasing permeation. This review discusses nanosystems with utility in skin delivery and focuses on the composition and characterization of ME and NE for topical and transdermal delivery. The mechanism of skin delivery across the stratum corneum and via hair follicles is reviewed with particular focus on the influence of formulation.https://www.mdpi.com/1999-4923/9/4/37microemulsionnanoemulsiontransdermalskin penetrationpenetration enhancernanosystem |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Christofori M. R. R. Nastiti Thellie Ponto Eman Abd Jeffrey E. Grice Heather A. E. Benson Michael S. Roberts |
spellingShingle |
Christofori M. R. R. Nastiti Thellie Ponto Eman Abd Jeffrey E. Grice Heather A. E. Benson Michael S. Roberts Topical Nano and Microemulsions for Skin Delivery Pharmaceutics microemulsion nanoemulsion transdermal skin penetration penetration enhancer nanosystem |
author_facet |
Christofori M. R. R. Nastiti Thellie Ponto Eman Abd Jeffrey E. Grice Heather A. E. Benson Michael S. Roberts |
author_sort |
Christofori M. R. R. Nastiti |
title |
Topical Nano and Microemulsions for Skin Delivery |
title_short |
Topical Nano and Microemulsions for Skin Delivery |
title_full |
Topical Nano and Microemulsions for Skin Delivery |
title_fullStr |
Topical Nano and Microemulsions for Skin Delivery |
title_full_unstemmed |
Topical Nano and Microemulsions for Skin Delivery |
title_sort |
topical nano and microemulsions for skin delivery |
publisher |
MDPI AG |
series |
Pharmaceutics |
issn |
1999-4923 |
publishDate |
2017-09-01 |
description |
Nanosystems such as microemulsions (ME) and nanoemulsions (NE) offer considerable opportunities for targeted drug delivery to and via the skin. ME and NE are stable colloidal systems composed of oil and water, stabilised by a mixture of surfactants and cosurfactants, that have received particular interest as topical skin delivery systems. There is considerable scope to manipulate the formulation components and characteristics to achieve optimal bioavailability and minimal skin irritancy. This includes the incorporation of established chemical penetration enhancers to fluidize the stratum corneum lipid bilayers, thus reducing the primary skin barrier and increasing permeation. This review discusses nanosystems with utility in skin delivery and focuses on the composition and characterization of ME and NE for topical and transdermal delivery. The mechanism of skin delivery across the stratum corneum and via hair follicles is reviewed with particular focus on the influence of formulation. |
topic |
microemulsion nanoemulsion transdermal skin penetration penetration enhancer nanosystem |
url |
https://www.mdpi.com/1999-4923/9/4/37 |
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