Synthesis and Anticancer Activity Evaluation of Novel Phenanthridine Derivatives

Synthesis and Anticancer Activity Evaluation of Novel Phenanthridine Derivatives

Based on the structure of sanguinarine, fourteen phenanthridine derivatives were designed and synthesized in the current study. The cytotoxic activities of synthesized compounds were evaluated against five human cancer cell lines (MCF-7, PC3, Hela, A549, and HepG2 cell lines) via MTT assay. Among al...

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Bibliographic Details
Main Authors:	Minghui Wan, Lei Zhang, Yiming Chen, Qiang Li, Wenli Fan, Qingxia Xue, Fang Yan, Weiguo Song
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-04-01
Series:	Frontiers in Oncology
Subjects:	phenanthridine anticancer topoisomerase apoptosis cell cycle arrest
Online Access:	https://www.frontiersin.org/article/10.3389/fonc.2019.00274/full

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