| Summary: | Introduction: Estimation of target dose with high precision is a key goal in pharmaceutical studiesthat achieving this goal depends greatly on an efficient design. One of these adequate designs is adaptivedesign. The median effective dose is an important dose that is criterion for assessment the power of amedicine. The purpose of this study was estimation of the median effective dose of anti spasmodicmedicine in adaptive design and comparison the precision of the estimation with conventional paralleldesign.Materials and Methods: Seventy guinea pigs were divided into seven groups (n=10) and each groupwas studied for one dose. One of the adaptive designs that uses frequently in pharmaceutical studies isup-and-down design. In this design, the number of samples in each dose was determined. Then forestimation of median effective dose, we used a method of the combination of dose-response logistic,dose-response log-linear, linear and Emax models and R software was used for data analysis.Result: In parallel design, number of samples in each dose was 10, but in adaptive design, number ofsamples in 10−3 and 10−4 doses was 21 and other doses were 7. MSE in parallel design was 59 and inadaptive design were 21. Estimation of median effective dose in dose-response logistic was8×10−5 , indose-response log-linear8×10−6 , in Emax 8×10−7 and in linear model was 5×10−6 . Using combinationof the four models in adaptive design, median effective dose was estimated12×10−5 .Conclusion: In addition to flexibility of adaptive design that concentrates the allocation ofobservations near the target dose, it seems this design is more efficient than parallel design in medicinalstudies.
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