VISTA deficiency attenuates antibody-induced arthritis and alters macrophage gene expression in response to simulated immune complexes

VISTA deficiency attenuates antibody-induced arthritis and alters macrophage gene expression in response to simulated immune complexes

Abstract Background In addition to activated T cells, the immune checkpoint inhibitor “V domain-containing Ig suppressor of T-cell activation” (VISTA) is expressed by myeloid cell types, including macrophages and neutrophils. The importance of VISTA expression by myeloid cells to antibody-induced ar...

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Bibliographic Details
Main Authors: Sabrina Ceeraz, Susan K. Eszterhas, Petra A. Sergent, David A. Armstrong, Alix Ashare, Thomas Broughton, Li Wang, Dov Pechenick, Christopher M. Burns, Randolph J. Noelle, Matthew P. Vincenti, Roy A. Fava
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Arthritis Research & Therapy
Subjects:
Arthritis
Macrophages
Antigen–antibody complex
Autoimmunity
Receptors
Complement
Online Access:http://link.springer.com/article/10.1186/s13075-017-1474-y

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