A SARS-CoV-2 familial cluster infection reveals asymptomatic transmission to children
Information on SARS-CoV-2 asymptomatic infection and infectivity in children is limited. In this study, we aimed to report the epidemiological and clinical characteristics of a familial cluster infection including children with SARS-CoV-2. On February 1, 2020, two children(case 1 and case 2), an 8-y...
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doaj-5d750bb1a7cd42ec86528507e36e2dca2020-11-25T03:05:28ZengElsevierJournal of Infection and Public Health1876-03412020-06-01136883886A SARS-CoV-2 familial cluster infection reveals asymptomatic transmission to childrenMing Chen0Panpan Fan1Zhi Liu2Rui Pan3Shaowu Huang4Junhua Li5Dongchi Zhao6Xiangyang Central Hospital, Affiliated Hospital Of Hubei University of Arts and Science, Xiangyang, China; Department of Pediatrics, Children's Digital Health and Data Center, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Pediatrics, Children's Digital Health and Data Center, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Pediatrics, Children's Digital Health and Data Center, Zhongnan Hospital of Wuhan University, Wuhan, ChinaXiangyang Central Hospital, Affiliated Hospital Of Hubei University of Arts and Science, Xiangyang, ChinaXiangyang Central Hospital, Affiliated Hospital Of Hubei University of Arts and Science, Xiangyang, ChinaXiangyang Central Hospital, Affiliated Hospital Of Hubei University of Arts and Science, Xiangyang, China; Corresponding author at: Xiangyang Central Hospital, Affiliated Hospital Of Hubei University of Arts and Science, Xiangyang 441100, China.Department of Pediatrics, Children's Digital Health and Data Center, Zhongnan Hospital of Wuhan University, Wuhan, China; Corresponding author at: Department of Pediatrics, Children's Digital Health and Data center, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.Information on SARS-CoV-2 asymptomatic infection and infectivity in children is limited. In this study, we aimed to report the epidemiological and clinical characteristics of a familial cluster infection including children with SARS-CoV-2. On February 1, 2020, two children(case 1 and case 2), an 8-year-old girl and a 9-year-old boy, were admitted to the isolation ward in Xiangyang Central Hospital, Hubei province, China, with the diagnosis of COVID-19. Before admission, they had been staying at home with their father and never contacted with any confirmed patients except their mother (case 3) who returned from Wuhan on January 22. Both case 1 and case 2 got mild symptoms. Case 3 did not develop any symptoms until February 6, 2020, with an asymptomatic period of 15 days. She was transferred to ICU and administered multiple treatment according to the disease progression and chest CT manifestations. Her nucleic acid test turned positive until Feb 21, 2020, 15 days after symptoms onset, 30 days after her return from Wuhan. Our data showed that patients with SARS-CoV-2 may have the ability to transmit during their asymptomatic period even with the negative of viral nucleic acid in pharyngeal swabs.http://www.sciencedirect.com/science/article/pii/S1876034120304846COVID-19SARS-CoV-2ChildrenAsymptomatic infectionsTransmission |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ming Chen Panpan Fan Zhi Liu Rui Pan Shaowu Huang Junhua Li Dongchi Zhao |
spellingShingle |
Ming Chen Panpan Fan Zhi Liu Rui Pan Shaowu Huang Junhua Li Dongchi Zhao A SARS-CoV-2 familial cluster infection reveals asymptomatic transmission to children Journal of Infection and Public Health COVID-19 SARS-CoV-2 Children Asymptomatic infections Transmission |
author_facet |
Ming Chen Panpan Fan Zhi Liu Rui Pan Shaowu Huang Junhua Li Dongchi Zhao |
author_sort |
Ming Chen |
title |
A SARS-CoV-2 familial cluster infection reveals asymptomatic transmission to children |
title_short |
A SARS-CoV-2 familial cluster infection reveals asymptomatic transmission to children |
title_full |
A SARS-CoV-2 familial cluster infection reveals asymptomatic transmission to children |
title_fullStr |
A SARS-CoV-2 familial cluster infection reveals asymptomatic transmission to children |
title_full_unstemmed |
A SARS-CoV-2 familial cluster infection reveals asymptomatic transmission to children |
title_sort |
sars-cov-2 familial cluster infection reveals asymptomatic transmission to children |
publisher |
Elsevier |
series |
Journal of Infection and Public Health |
issn |
1876-0341 |
publishDate |
2020-06-01 |
description |
Information on SARS-CoV-2 asymptomatic infection and infectivity in children is limited. In this study, we aimed to report the epidemiological and clinical characteristics of a familial cluster infection including children with SARS-CoV-2. On February 1, 2020, two children(case 1 and case 2), an 8-year-old girl and a 9-year-old boy, were admitted to the isolation ward in Xiangyang Central Hospital, Hubei province, China, with the diagnosis of COVID-19. Before admission, they had been staying at home with their father and never contacted with any confirmed patients except their mother (case 3) who returned from Wuhan on January 22. Both case 1 and case 2 got mild symptoms. Case 3 did not develop any symptoms until February 6, 2020, with an asymptomatic period of 15 days. She was transferred to ICU and administered multiple treatment according to the disease progression and chest CT manifestations. Her nucleic acid test turned positive until Feb 21, 2020, 15 days after symptoms onset, 30 days after her return from Wuhan. Our data showed that patients with SARS-CoV-2 may have the ability to transmit during their asymptomatic period even with the negative of viral nucleic acid in pharyngeal swabs. |
topic |
COVID-19 SARS-CoV-2 Children Asymptomatic infections Transmission |
url |
http://www.sciencedirect.com/science/article/pii/S1876034120304846 |
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