Antiphospholipid Syndrome and Kidney Involvement: New Insights

• Main Authors: José A. Martínez-Flores, Manuel Serrano, Jose M. Morales, Antonio Serrano
• Format: Article
• Language: English
• Published: MDPI AG 2016-07-01
• Series: Antibodies
• Subjects: autoimmunity; antiphospholipid antibodies; end stage kidney disease; early graft loss; thrombosis antiphospholipid syndrome; aPL; B2GPI; IgA
• Online Access: http://www.mdpi.com/2073-4468/5/3/17

Antiphospholipid syndrome is an autoimmune disorder characterized by vascular thromboses and pregnancy morbidity associated with antiphospholipid antibodies: lupus anticoagulant, IgG or IgM anticardiolipin or anti-beta 2-glycoprotein I. The kidney is one of the major target organs in antiphospholipid syndrome (APS). However, beyond the known involvement of the kidney in primary and associated APS, we may be observing a new form of APS within the context of renal failure. This review describes the classical kidney manifestations of APS and provides new considerations to be taken into account.