KRAB-Induced Heterochromatin Effectively Silences <i>PLOD2</i> Gene Expression in Somatic Cells and is Resilient to TGFβ1 Activation

KRAB-Induced Heterochromatin Effectively Silences <i>PLOD2</i> Gene Expression in Somatic Cells and is Resilient to TGFβ1 Activation

Epigenetic editing, an emerging technique used for the modulation of gene expression in mammalian cells, is a promising strategy to correct disease-related gene expression. Although epigenetic reprogramming results in sustained transcriptional modulation in several in vivo models, further studies ar...

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Bibliographic Details
Main Authors: Rutger A. F. Gjaltema, Désirée Goubert, Christian Huisman, Consuelo del Pilar García Tobilla, Mihály Koncz, Pytrick G. Jellema, Dandan Wu, Uilke Brouwer, Antal Kiss, Pernette J. Verschure, Ruud A. Bank, Marianne G. Rots
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
epigenetic editing
KRAB
gene repression
<i>PLOD2</i>
fibrosis
cancer
Online Access:https://www.mdpi.com/1422-0067/21/10/3634

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