White Matter Microstructure Alterations in Patients With Spinal Cord Injury Assessed by Diffusion Tensor Imaging
Compared to healthy controls, spinal cord injury (SCI) patients demonstrate white matter (WM) abnormalities in the brain. However, little progress has been made in comparing cerebral WM differences between SCI-subgroups. The purpose of this study was to investigate WM microstructure differences betw...
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Frontiers Media S.A.
2019-02-01
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Online Access: | https://www.frontiersin.org/article/10.3389/fnhum.2019.00011/full |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yun Guo Yun Guo Yun Guo Yun Guo Yun Guo Feng Gao Feng Gao Feng Gao Feng Gao Feng Gao Yaou Liu Hua Guo Weiyong Yu Zhenbo Chen Mingliang Yang Mingliang Yang Mingliang Yang Mingliang Yang Mingliang Yang Liangjie Du Liangjie Du Liangjie Du Liangjie Du Liangjie Du Degang Yang Degang Yang Degang Yang Degang Yang Degang Yang Jianjun Li Jianjun Li Jianjun Li Jianjun Li Jianjun Li |
spellingShingle |
Yun Guo Yun Guo Yun Guo Yun Guo Yun Guo Feng Gao Feng Gao Feng Gao Feng Gao Feng Gao Yaou Liu Hua Guo Weiyong Yu Zhenbo Chen Mingliang Yang Mingliang Yang Mingliang Yang Mingliang Yang Mingliang Yang Liangjie Du Liangjie Du Liangjie Du Liangjie Du Liangjie Du Degang Yang Degang Yang Degang Yang Degang Yang Degang Yang Jianjun Li Jianjun Li Jianjun Li Jianjun Li Jianjun Li White Matter Microstructure Alterations in Patients With Spinal Cord Injury Assessed by Diffusion Tensor Imaging Frontiers in Human Neuroscience spinal cord injury cerebral white matter microstructure diffusion tensor imaging tract-based spatial statistics atlas-based analysis |
author_facet |
Yun Guo Yun Guo Yun Guo Yun Guo Yun Guo Feng Gao Feng Gao Feng Gao Feng Gao Feng Gao Yaou Liu Hua Guo Weiyong Yu Zhenbo Chen Mingliang Yang Mingliang Yang Mingliang Yang Mingliang Yang Mingliang Yang Liangjie Du Liangjie Du Liangjie Du Liangjie Du Liangjie Du Degang Yang Degang Yang Degang Yang Degang Yang Degang Yang Jianjun Li Jianjun Li Jianjun Li Jianjun Li Jianjun Li |
author_sort |
Yun Guo |
title |
White Matter Microstructure Alterations in Patients With Spinal Cord Injury Assessed by Diffusion Tensor Imaging |
title_short |
White Matter Microstructure Alterations in Patients With Spinal Cord Injury Assessed by Diffusion Tensor Imaging |
title_full |
White Matter Microstructure Alterations in Patients With Spinal Cord Injury Assessed by Diffusion Tensor Imaging |
title_fullStr |
White Matter Microstructure Alterations in Patients With Spinal Cord Injury Assessed by Diffusion Tensor Imaging |
title_full_unstemmed |
White Matter Microstructure Alterations in Patients With Spinal Cord Injury Assessed by Diffusion Tensor Imaging |
title_sort |
white matter microstructure alterations in patients with spinal cord injury assessed by diffusion tensor imaging |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Human Neuroscience |
issn |
1662-5161 |
publishDate |
2019-02-01 |
description |
Compared to healthy controls, spinal cord injury (SCI) patients demonstrate white matter (WM) abnormalities in the brain. However, little progress has been made in comparing cerebral WM differences between SCI-subgroups. The purpose of this study was to investigate WM microstructure differences between paraplegia and quadriplegia using tract-based spatial statistics (TBSS) and atlas-based analysis methods. Twenty-two SCI patients (11 cervical SCI and 11 thoracic SCI) and 22 age- and sex-matched healthy controls were included in this study. TBSS and atlas-based analyses were performed between SCI and control groups and between SCI-subgroups using multiple diffusion metrics, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD). Compared to controls, SCI patients had decreased FA and increased MD and RD in the corpus callosum (CC; genu and splenium), superior longitudinal fasciculus (SLF), corona radiata (CR), posterior thalamic radiation (PTR), right cingulum (cingulate gyrus; CCG) and right superior fronto-occipital fasciculus (SFOF). Cervical SCI patients had lower FA and higher RD in the left PTR than thoracic SCI patients. Time since injury had a negative correlation with FA within the right SFOF (r = −0.452, p = 0.046) and a positive association between the FA of left PTR and the American Spinal Injury Association (ASIA) sensory score (r = 0.428, p = 0.047). In conclusion, our study suggests that multiple cerebral WM tracts are damaged in SCI patients, and WM disruption in cervical SCI is worse than thoracic injury level, especially in the PTR region. |
topic |
spinal cord injury cerebral white matter microstructure diffusion tensor imaging tract-based spatial statistics atlas-based analysis |
url |
https://www.frontiersin.org/article/10.3389/fnhum.2019.00011/full |
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doaj-5d7d1c5aab3b43259cc70ecaf4691f0a2020-11-25T03:15:05ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612019-02-011310.3389/fnhum.2019.00011418509White Matter Microstructure Alterations in Patients With Spinal Cord Injury Assessed by Diffusion Tensor ImagingYun Guo0Yun Guo1Yun Guo2Yun Guo3Yun Guo4Feng Gao5Feng Gao6Feng Gao7Feng Gao8Feng Gao9Yaou Liu10Hua Guo11Weiyong Yu12Zhenbo Chen13Mingliang Yang14Mingliang Yang15Mingliang Yang16Mingliang Yang17Mingliang Yang18Liangjie Du19Liangjie Du20Liangjie Du21Liangjie Du22Liangjie Du23Degang Yang24Degang Yang25Degang Yang26Degang Yang27Degang Yang28Jianjun Li29Jianjun Li30Jianjun Li31Jianjun Li32Jianjun Li33School of Rehabilitation Medicine, Capital Medical University, Beijing, ChinaChina Rehabilitation Research Center, Department of Spinal and Neural Functional Reconstruction, Beijing, ChinaCenter of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, ChinaChina Rehabilitation Science Institute, Beijing, ChinaBeijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, ChinaSchool of Rehabilitation Medicine, Capital Medical University, Beijing, ChinaChina Rehabilitation Research Center, Department of Spinal and Neural Functional Reconstruction, Beijing, ChinaCenter of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, ChinaChina Rehabilitation Science Institute, Beijing, ChinaBeijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, ChinaDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaCenter for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, ChinaChina Rehabilitation Research Center, Department of Radiology, Beijing, ChinaChina Rehabilitation Research Center, Department of Radiology, Beijing, ChinaSchool of Rehabilitation Medicine, Capital Medical University, Beijing, ChinaChina Rehabilitation Research Center, Department of Spinal and Neural Functional Reconstruction, Beijing, ChinaCenter of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, ChinaChina Rehabilitation Science Institute, Beijing, ChinaBeijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, ChinaSchool of Rehabilitation Medicine, Capital Medical University, Beijing, ChinaChina Rehabilitation Research Center, Department of Spinal and Neural Functional Reconstruction, Beijing, ChinaCenter of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, ChinaChina Rehabilitation Science Institute, Beijing, ChinaBeijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, ChinaSchool of Rehabilitation Medicine, Capital Medical University, Beijing, ChinaChina Rehabilitation Research Center, Department of Spinal and Neural Functional Reconstruction, Beijing, ChinaCenter of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, ChinaChina Rehabilitation Science Institute, Beijing, ChinaBeijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, ChinaSchool of Rehabilitation Medicine, Capital Medical University, Beijing, ChinaChina Rehabilitation Research Center, Department of Spinal and Neural Functional Reconstruction, Beijing, ChinaCenter of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, ChinaChina Rehabilitation Science Institute, Beijing, ChinaBeijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, ChinaCompared to healthy controls, spinal cord injury (SCI) patients demonstrate white matter (WM) abnormalities in the brain. However, little progress has been made in comparing cerebral WM differences between SCI-subgroups. The purpose of this study was to investigate WM microstructure differences between paraplegia and quadriplegia using tract-based spatial statistics (TBSS) and atlas-based analysis methods. Twenty-two SCI patients (11 cervical SCI and 11 thoracic SCI) and 22 age- and sex-matched healthy controls were included in this study. TBSS and atlas-based analyses were performed between SCI and control groups and between SCI-subgroups using multiple diffusion metrics, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD). Compared to controls, SCI patients had decreased FA and increased MD and RD in the corpus callosum (CC; genu and splenium), superior longitudinal fasciculus (SLF), corona radiata (CR), posterior thalamic radiation (PTR), right cingulum (cingulate gyrus; CCG) and right superior fronto-occipital fasciculus (SFOF). Cervical SCI patients had lower FA and higher RD in the left PTR than thoracic SCI patients. Time since injury had a negative correlation with FA within the right SFOF (r = −0.452, p = 0.046) and a positive association between the FA of left PTR and the American Spinal Injury Association (ASIA) sensory score (r = 0.428, p = 0.047). In conclusion, our study suggests that multiple cerebral WM tracts are damaged in SCI patients, and WM disruption in cervical SCI is worse than thoracic injury level, especially in the PTR region.https://www.frontiersin.org/article/10.3389/fnhum.2019.00011/fullspinal cord injurycerebral white matter microstructurediffusion tensor imagingtract-based spatial statisticsatlas-based analysis |