Evaluation of Serum Vaspin and Chemerin Levels in Type 2 Diabetic and Treated with Anti Diabetic Drugs Metformin and Acarbose in Rats
Background & Objective: The serum levels of adipose tissue hormons, Vaspin and Chemerin, alter in some disorder conditions such as diabetes. The aim of this study is to investigate the effect of two anti-diabetic drugs (Metformin and Acarbose) and their combination on serum concentration of Vasp...
Main Authors: | , , , |
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Format: | Article |
Language: | fas |
Published: |
Fasa University of Medical Sciences
2015-05-01
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Series: | Journal of Fasa University of Medical Sciences |
Subjects: | |
Online Access: | http://journal.fums.ac.ir/browse.php?a_code=A-10-763-1&slc_lang=en&sid=1 |
Summary: | Background
& Objective:
The serum levels of adipose tissue hormons, Vaspin and Chemerin,
alter in some disorder conditions such as diabetes. The aim of this study is to
investigate the effect of two anti-diabetic drugs (Metformin and Acarbose) and
their combination on serum concentration of Vaspin and Chemerin in type 2
diabetic rats. Materials
& Methods:
30
male, wistar rats are randomly divided into 5 groups, while 4 groups are
suffered from type 2 diabetes, and 3 groups of these diabetics are cured using
metformin, acarbose, and combination of both, respectively, during 6 weeks.
Body weight, fasting glucose, glycated hemoglobin, lipid profile, and serum’s
vaspin and chemerin are being examined. Statistic data are analyzed using SPSS
software. Results report by mean ±
standard deviation, and statistic difference considers significant by P˂0.05. Results:
Findings
of this study show a significant decrease for vaspin (P=0.001) and a
significant increase for chemerin levels (P=0.004) in diabetic control group
compared with normal control group. Treatment of all groups show a significant
increase in serum levels of vaspin (P=0.001) while treatment by metformin results
in a significant decrease in chemerin level in this group (P=0.036). In this
study, fasting blood glucose, glycated hemoglobin, and lipid profile in treated
group with both of drugs show decrease that is more significant. Conclusion:
Probably
metformin and acarbose through increase of serum level of vaspin leads to
reduction of insulin resistance. |
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ISSN: | 2228-5105 2228-7329 |