Evaluation of Serum Vaspin and Chemerin Levels in Type 2 Diabetic and Treated with Anti Diabetic Drugs Metformin and Acarbose in Rats
Background & Objective: The serum levels of adipose tissue hormons, Vaspin and Chemerin, alter in some disorder conditions such as diabetes. The aim of this study is to investigate the effect of two anti-diabetic drugs (Metformin and Acarbose) and their combination on serum concentration of Vasp...
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doaj-5d85fb8d79e443aebfd672d7cce14b512020-11-24T21:49:59ZfasFasa University of Medical SciencesJournal of Fasa University of Medical Sciences2228-51052228-73292015-05-0151120133Evaluation of Serum Vaspin and Chemerin Levels in Type 2 Diabetic and Treated with Anti Diabetic Drugs Metformin and Acarbose in RatsSeyed Mohammad Ali Ghaffari0Mohammad taghi Mansouri1Mohammad Hossein Haghighizadeh2Elham Rafie3 Department of Biochemistry and Cellular and Molecular Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Department of Pharmacology, Faculty of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Department of Statistics, Faculty of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Medical and Molecular Research Center, Arak University of Medical Sciences, Arak, Iran. Background & Objective: The serum levels of adipose tissue hormons, Vaspin and Chemerin, alter in some disorder conditions such as diabetes. The aim of this study is to investigate the effect of two anti-diabetic drugs (Metformin and Acarbose) and their combination on serum concentration of Vaspin and Chemerin in type 2 diabetic rats. Materials & Methods: 30 male, wistar rats are randomly divided into 5 groups, while 4 groups are suffered from type 2 diabetes, and 3 groups of these diabetics are cured using metformin, acarbose, and combination of both, respectively, during 6 weeks. Body weight, fasting glucose, glycated hemoglobin, lipid profile, and serum’s vaspin and chemerin are being examined. Statistic data are analyzed using SPSS software. Results report by mean ± standard deviation, and statistic difference considers significant by P˂0.05. Results: Findings of this study show a significant decrease for vaspin (P=0.001) and a significant increase for chemerin levels (P=0.004) in diabetic control group compared with normal control group. Treatment of all groups show a significant increase in serum levels of vaspin (P=0.001) while treatment by metformin results in a significant decrease in chemerin level in this group (P=0.036). In this study, fasting blood glucose, glycated hemoglobin, and lipid profile in treated group with both of drugs show decrease that is more significant. Conclusion: Probably metformin and acarbose through increase of serum level of vaspin leads to reduction of insulin resistance.http://journal.fums.ac.ir/browse.php?a_code=A-10-763-1&slc_lang=en&sid=1Acarbose Metformin Type 2 Diabetes Rat Vaspin Chemerin |
collection |
DOAJ |
language |
fas |
format |
Article |
sources |
DOAJ |
author |
Seyed Mohammad Ali Ghaffari Mohammad taghi Mansouri Mohammad Hossein Haghighizadeh Elham Rafie |
spellingShingle |
Seyed Mohammad Ali Ghaffari Mohammad taghi Mansouri Mohammad Hossein Haghighizadeh Elham Rafie Evaluation of Serum Vaspin and Chemerin Levels in Type 2 Diabetic and Treated with Anti Diabetic Drugs Metformin and Acarbose in Rats Journal of Fasa University of Medical Sciences Acarbose Metformin Type 2 Diabetes Rat Vaspin Chemerin |
author_facet |
Seyed Mohammad Ali Ghaffari Mohammad taghi Mansouri Mohammad Hossein Haghighizadeh Elham Rafie |
author_sort |
Seyed Mohammad Ali Ghaffari |
title |
Evaluation of Serum Vaspin and Chemerin Levels in Type 2 Diabetic and Treated with Anti Diabetic Drugs Metformin and Acarbose in Rats |
title_short |
Evaluation of Serum Vaspin and Chemerin Levels in Type 2 Diabetic and Treated with Anti Diabetic Drugs Metformin and Acarbose in Rats |
title_full |
Evaluation of Serum Vaspin and Chemerin Levels in Type 2 Diabetic and Treated with Anti Diabetic Drugs Metformin and Acarbose in Rats |
title_fullStr |
Evaluation of Serum Vaspin and Chemerin Levels in Type 2 Diabetic and Treated with Anti Diabetic Drugs Metformin and Acarbose in Rats |
title_full_unstemmed |
Evaluation of Serum Vaspin and Chemerin Levels in Type 2 Diabetic and Treated with Anti Diabetic Drugs Metformin and Acarbose in Rats |
title_sort |
evaluation of serum vaspin and chemerin levels in type 2 diabetic and treated with anti diabetic drugs metformin and acarbose in rats |
publisher |
Fasa University of Medical Sciences |
series |
Journal of Fasa University of Medical Sciences |
issn |
2228-5105 2228-7329 |
publishDate |
2015-05-01 |
description |
Background
& Objective:
The serum levels of adipose tissue hormons, Vaspin and Chemerin,
alter in some disorder conditions such as diabetes. The aim of this study is to
investigate the effect of two anti-diabetic drugs (Metformin and Acarbose) and
their combination on serum concentration of Vaspin and Chemerin in type 2
diabetic rats. Materials
& Methods:
30
male, wistar rats are randomly divided into 5 groups, while 4 groups are
suffered from type 2 diabetes, and 3 groups of these diabetics are cured using
metformin, acarbose, and combination of both, respectively, during 6 weeks.
Body weight, fasting glucose, glycated hemoglobin, lipid profile, and serum’s
vaspin and chemerin are being examined. Statistic data are analyzed using SPSS
software. Results report by mean ±
standard deviation, and statistic difference considers significant by P˂0.05. Results:
Findings
of this study show a significant decrease for vaspin (P=0.001) and a
significant increase for chemerin levels (P=0.004) in diabetic control group
compared with normal control group. Treatment of all groups show a significant
increase in serum levels of vaspin (P=0.001) while treatment by metformin results
in a significant decrease in chemerin level in this group (P=0.036). In this
study, fasting blood glucose, glycated hemoglobin, and lipid profile in treated
group with both of drugs show decrease that is more significant. Conclusion:
Probably
metformin and acarbose through increase of serum level of vaspin leads to
reduction of insulin resistance. |
topic |
Acarbose Metformin Type 2 Diabetes Rat Vaspin Chemerin |
url |
http://journal.fums.ac.ir/browse.php?a_code=A-10-763-1&slc_lang=en&sid=1 |
work_keys_str_mv |
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