The Regulatory Network and Potential Role of LINC00973-miRNA-mRNA ceRNA in the Progression of Non-Small-Cell Lung Cancer
BackgroundThe occurrence and development of cancer could be promoted by abnormally competing endogenous RNAs (ceRNA) network. This article aims to determine the prognostic biomarker of ceRNA for non-small-cell lung cancer (NSCLC) prognosis.MethodsThe expression and clinical significance of LINC00973...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-07-01
|
Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.684807/full |
id |
doaj-5d9b2440d772475aab602c98cbcd7c9d |
---|---|
record_format |
Article |
spelling |
doaj-5d9b2440d772475aab602c98cbcd7c9d2021-07-29T09:32:44ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-07-011210.3389/fimmu.2021.684807684807The Regulatory Network and Potential Role of LINC00973-miRNA-mRNA ceRNA in the Progression of Non-Small-Cell Lung CancerQiang Guo0Dan Li1Xiangyu Luo2Ye Yuan3Tian Li4Huasong Liu5Xinju Wang6Xinju Wang7Department of Cardiothoracic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, ChinaDepartment of Oncology, Huanggang Central Hospital, Huanggang, ChinaDepartment of Cardiothoracic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, ChinaDepartment of Cardiothoracic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, ChinaSchool of Basic Medicine, Fourth Military Medical University, Xi’an, ChinaDepartment of Cardiothoracic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, ChinaDepartment of Cardiothoracic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, ChinaDepartment of Respiratory, Xinchang People’s Hospital, Xinchang, ChinaBackgroundThe occurrence and development of cancer could be promoted by abnormally competing endogenous RNAs (ceRNA) network. This article aims to determine the prognostic biomarker of ceRNA for non-small-cell lung cancer (NSCLC) prognosis.MethodsThe expression and clinical significance of LINC00973 in NSCLC tissues were analyzed via the The Cancer Genome Atlas (TCGA), Gene Expression Profiling Interactive Analysis (GEPIA), lnCAR, and clinical samples in Taihe Hospital. The biological functions and signaling pathways involved in target genes of ceRNA network were analyzed via Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Survival analysis, univariate and multivariate Cox regression analysis were used for prognostic-related mRNA.ResultsExpression of LINC00973 was increased in NSCLC tissues. High expression of LINC00973 was associated with poor prognosis of NSCLC patients. There were 15 miRNA and 238 differential mRNA in the INC00973-miRNA-mRNA ceRNA network, involving cell migration, endothelial cell proliferation, tumor growth factor (TGF)-β, cellular senescence, phosphatidylinositol 3-hydroxy kinase (PI3K)-Akt, Hippo, Rap1, mitogen-activated protein kinase (MAPK), cell cycle signaling pathway, etc. The expression levels of RTKN2, NFIX, PTX3, BMP2 and LOXL2 were independent risk factors for the poor prognosis of NSCLC patients.ConclusionsLINC00973-miRNA-mRNA ceRNA network might be the basis for determining pivotal post-translational regulatory mechanisms in the progression of NSCLC. BMP2, LOXL2, NFIX, PTX3 and RTKN2 might be valuable prognostic markers and potential therapeutic targets.https://www.frontiersin.org/articles/10.3389/fimmu.2021.684807/fullLINC00973non-small cell lung cancerprognosisbiomarkerceRNA |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qiang Guo Dan Li Xiangyu Luo Ye Yuan Tian Li Huasong Liu Xinju Wang Xinju Wang |
spellingShingle |
Qiang Guo Dan Li Xiangyu Luo Ye Yuan Tian Li Huasong Liu Xinju Wang Xinju Wang The Regulatory Network and Potential Role of LINC00973-miRNA-mRNA ceRNA in the Progression of Non-Small-Cell Lung Cancer Frontiers in Immunology LINC00973 non-small cell lung cancer prognosis biomarker ceRNA |
author_facet |
Qiang Guo Dan Li Xiangyu Luo Ye Yuan Tian Li Huasong Liu Xinju Wang Xinju Wang |
author_sort |
Qiang Guo |
title |
The Regulatory Network and Potential Role of LINC00973-miRNA-mRNA ceRNA in the Progression of Non-Small-Cell Lung Cancer |
title_short |
The Regulatory Network and Potential Role of LINC00973-miRNA-mRNA ceRNA in the Progression of Non-Small-Cell Lung Cancer |
title_full |
The Regulatory Network and Potential Role of LINC00973-miRNA-mRNA ceRNA in the Progression of Non-Small-Cell Lung Cancer |
title_fullStr |
The Regulatory Network and Potential Role of LINC00973-miRNA-mRNA ceRNA in the Progression of Non-Small-Cell Lung Cancer |
title_full_unstemmed |
The Regulatory Network and Potential Role of LINC00973-miRNA-mRNA ceRNA in the Progression of Non-Small-Cell Lung Cancer |
title_sort |
regulatory network and potential role of linc00973-mirna-mrna cerna in the progression of non-small-cell lung cancer |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2021-07-01 |
description |
BackgroundThe occurrence and development of cancer could be promoted by abnormally competing endogenous RNAs (ceRNA) network. This article aims to determine the prognostic biomarker of ceRNA for non-small-cell lung cancer (NSCLC) prognosis.MethodsThe expression and clinical significance of LINC00973 in NSCLC tissues were analyzed via the The Cancer Genome Atlas (TCGA), Gene Expression Profiling Interactive Analysis (GEPIA), lnCAR, and clinical samples in Taihe Hospital. The biological functions and signaling pathways involved in target genes of ceRNA network were analyzed via Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Survival analysis, univariate and multivariate Cox regression analysis were used for prognostic-related mRNA.ResultsExpression of LINC00973 was increased in NSCLC tissues. High expression of LINC00973 was associated with poor prognosis of NSCLC patients. There were 15 miRNA and 238 differential mRNA in the INC00973-miRNA-mRNA ceRNA network, involving cell migration, endothelial cell proliferation, tumor growth factor (TGF)-β, cellular senescence, phosphatidylinositol 3-hydroxy kinase (PI3K)-Akt, Hippo, Rap1, mitogen-activated protein kinase (MAPK), cell cycle signaling pathway, etc. The expression levels of RTKN2, NFIX, PTX3, BMP2 and LOXL2 were independent risk factors for the poor prognosis of NSCLC patients.ConclusionsLINC00973-miRNA-mRNA ceRNA network might be the basis for determining pivotal post-translational regulatory mechanisms in the progression of NSCLC. BMP2, LOXL2, NFIX, PTX3 and RTKN2 might be valuable prognostic markers and potential therapeutic targets. |
topic |
LINC00973 non-small cell lung cancer prognosis biomarker ceRNA |
url |
https://www.frontiersin.org/articles/10.3389/fimmu.2021.684807/full |
work_keys_str_mv |
AT qiangguo theregulatorynetworkandpotentialroleoflinc00973mirnamrnacernaintheprogressionofnonsmallcelllungcancer AT danli theregulatorynetworkandpotentialroleoflinc00973mirnamrnacernaintheprogressionofnonsmallcelllungcancer AT xiangyuluo theregulatorynetworkandpotentialroleoflinc00973mirnamrnacernaintheprogressionofnonsmallcelllungcancer AT yeyuan theregulatorynetworkandpotentialroleoflinc00973mirnamrnacernaintheprogressionofnonsmallcelllungcancer AT tianli theregulatorynetworkandpotentialroleoflinc00973mirnamrnacernaintheprogressionofnonsmallcelllungcancer AT huasongliu theregulatorynetworkandpotentialroleoflinc00973mirnamrnacernaintheprogressionofnonsmallcelllungcancer AT xinjuwang theregulatorynetworkandpotentialroleoflinc00973mirnamrnacernaintheprogressionofnonsmallcelllungcancer AT xinjuwang theregulatorynetworkandpotentialroleoflinc00973mirnamrnacernaintheprogressionofnonsmallcelllungcancer AT qiangguo regulatorynetworkandpotentialroleoflinc00973mirnamrnacernaintheprogressionofnonsmallcelllungcancer AT danli regulatorynetworkandpotentialroleoflinc00973mirnamrnacernaintheprogressionofnonsmallcelllungcancer AT xiangyuluo regulatorynetworkandpotentialroleoflinc00973mirnamrnacernaintheprogressionofnonsmallcelllungcancer AT yeyuan regulatorynetworkandpotentialroleoflinc00973mirnamrnacernaintheprogressionofnonsmallcelllungcancer AT tianli regulatorynetworkandpotentialroleoflinc00973mirnamrnacernaintheprogressionofnonsmallcelllungcancer AT huasongliu regulatorynetworkandpotentialroleoflinc00973mirnamrnacernaintheprogressionofnonsmallcelllungcancer AT xinjuwang regulatorynetworkandpotentialroleoflinc00973mirnamrnacernaintheprogressionofnonsmallcelllungcancer AT xinjuwang regulatorynetworkandpotentialroleoflinc00973mirnamrnacernaintheprogressionofnonsmallcelllungcancer |
_version_ |
1721248939512954880 |