Multiplex RNA‐based detection of clinically relevant MET alterations in advanced non‐small cell lung cancer

Multiplex RNA‐based detection of clinically relevant MET alterations in advanced non‐small cell lung cancer

MET inhibitors have shown activity in non‐small‐cell lung cancer patients (NSCLC) with MET amplification and exon 14 skipping (METΔex14). However, patient stratification is imperfect, and thus, response rates have varied widely. Here, we studied MET alterations in 474 advanced NSCLC patients by nCou...

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Main Authors: Cristina Aguado, Cristina Teixido, Ruth Román, Roxana Reyes, Ana Giménez‐Capitán, Elba Marin, Carlos Cabrera, Nuria Viñolas, Sergi Castillo, Silvia Muñoz, Ainara Arcocha, Laura López‐Vilaró, Ivana Sullivan, Erika Aldeguer, Sonia Rodríguez, Irene Moya, Santiago Viteri, Andrés Felipe Cardona, Ramon Palmero, Cristina Sainz, Miguel Mesa‐Guzmán, Maria D. Lozano, Andrés Aguilar‐Hernández, Alejandro Martínez‐Bueno, María González‐Cao, Elena Gonzalvo, William P. J. Leenders, Rafael Rosell, Luis M. Montuenga, Aleix Prat, Miguel A. Molina‐Vila, Noemi Reguart
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Molecular Oncology
Subjects:
amplification
expression
lung cancer
MET
RNA
skipping
Online Access:https://doi.org/10.1002/1878-0261.12861

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