Decreased CSF Levels of ß-Amyloid in Patients With Cortical Superficial Siderosis
Background: Cortical superficial siderosis (cSS) represents a key neuroimaging marker of cerebral amyloid angiopathy (CAA) that is associated with intracranial hemorrhages and cognitive impairment. Nevertheless, the association between cSS and core cerebrospinal fluid (CSF) biomarkers for dementia r...
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doaj-5dc186c1199d48b9b41974a211cd3c2c2020-11-25T01:01:45ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-04-011010.3389/fneur.2019.00439455936Decreased CSF Levels of ß-Amyloid in Patients With Cortical Superficial SiderosisCihan Catak0Marialuisa Zedde1Rainer Malik2Daniel Janowitz3Vivian Soric4Anna Seegerer5Alexander Krebs6Marco Düring7Christian Opherk8Jennifer Linn9Frank A. Wollenweber10Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, GermanyNeurology Unit, Stroke Unit, Arcispedale Santa Maria Nuova, Azienda Unità Sanitaria Locale-IRCCS Reggio Emilia, Reggio Emilia, ItalyInstitute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, GermanyInstitute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, GermanyInstitute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, GermanyInstitute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, GermanyMVZ Labor PD Dr. Volkmann und Kollegen, Gesellschaft Bürgerlichen Rechts, Karlsruhe, GermanyInstitute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, GermanyKlinik für Neurologie, SLK-Kliniken Heilbronn GmbH, Heilbronn, GermanyInstitut und Poliklinik für Neuroradiologie, University Hospital Carl Gustav Carus, Dresden, GermanyInstitute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, GermanyBackground: Cortical superficial siderosis (cSS) represents a key neuroimaging marker of cerebral amyloid angiopathy (CAA) that is associated with intracranial hemorrhages and cognitive impairment. Nevertheless, the association between cSS and core cerebrospinal fluid (CSF) biomarkers for dementia remain unclear.Methods: One hundred and one patients with probable (79%, 80/101) or possible (21%, 21/101) CAA according to the modified Boston criteria and mild cognitive impairment according to Petersen criteria were prospectively included between 2011 and 2016. CSF analyses of ß-amyloid 42, ß-amyloid 40, total tau and phosphorylated tau were performed using sandwich-type enzyme-linked immunosorbent-assay. All patients received MRI and Mini-Mental-State Examination (MMSE). Logistic regression analysis was used to adjust for possible confounders.Results: cSS was present in 61% (62/101). Of those, 53% (33/62) had disseminated cSS and 47% (29/62) focal cSS. ß-amyloid 42 was lower in patients with cSS than in patients without cSS (OR 0.2; 95% CI 0.08–0.6; p = 0.0052) and lower in patients with disseminated cSS than in those with focal cSS (OR 0.02; 95% CI 0.003–0.2; p = 0.00057). Presence of cSS had no association with regard to ß-amyloid 40, total tau and phosphorylated tau.Conclusions: Our results demonstrate that the presence and extent of cSS are associated with reduced CSF ß-amyloid 42 levels. Further studies are needed to investigate the underlying mechanisms of this association.https://www.frontiersin.org/article/10.3389/fneur.2019.00439/fullcerebral amyloid angiopathycortical superficial siderosiscerebrospinal fluidcerebral microbleedsneuroimaging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cihan Catak Marialuisa Zedde Rainer Malik Daniel Janowitz Vivian Soric Anna Seegerer Alexander Krebs Marco Düring Christian Opherk Jennifer Linn Frank A. Wollenweber |
spellingShingle |
Cihan Catak Marialuisa Zedde Rainer Malik Daniel Janowitz Vivian Soric Anna Seegerer Alexander Krebs Marco Düring Christian Opherk Jennifer Linn Frank A. Wollenweber Decreased CSF Levels of ß-Amyloid in Patients With Cortical Superficial Siderosis Frontiers in Neurology cerebral amyloid angiopathy cortical superficial siderosis cerebrospinal fluid cerebral microbleeds neuroimaging |
author_facet |
Cihan Catak Marialuisa Zedde Rainer Malik Daniel Janowitz Vivian Soric Anna Seegerer Alexander Krebs Marco Düring Christian Opherk Jennifer Linn Frank A. Wollenweber |
author_sort |
Cihan Catak |
title |
Decreased CSF Levels of ß-Amyloid in Patients With Cortical Superficial Siderosis |
title_short |
Decreased CSF Levels of ß-Amyloid in Patients With Cortical Superficial Siderosis |
title_full |
Decreased CSF Levels of ß-Amyloid in Patients With Cortical Superficial Siderosis |
title_fullStr |
Decreased CSF Levels of ß-Amyloid in Patients With Cortical Superficial Siderosis |
title_full_unstemmed |
Decreased CSF Levels of ß-Amyloid in Patients With Cortical Superficial Siderosis |
title_sort |
decreased csf levels of ß-amyloid in patients with cortical superficial siderosis |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2019-04-01 |
description |
Background: Cortical superficial siderosis (cSS) represents a key neuroimaging marker of cerebral amyloid angiopathy (CAA) that is associated with intracranial hemorrhages and cognitive impairment. Nevertheless, the association between cSS and core cerebrospinal fluid (CSF) biomarkers for dementia remain unclear.Methods: One hundred and one patients with probable (79%, 80/101) or possible (21%, 21/101) CAA according to the modified Boston criteria and mild cognitive impairment according to Petersen criteria were prospectively included between 2011 and 2016. CSF analyses of ß-amyloid 42, ß-amyloid 40, total tau and phosphorylated tau were performed using sandwich-type enzyme-linked immunosorbent-assay. All patients received MRI and Mini-Mental-State Examination (MMSE). Logistic regression analysis was used to adjust for possible confounders.Results: cSS was present in 61% (62/101). Of those, 53% (33/62) had disseminated cSS and 47% (29/62) focal cSS. ß-amyloid 42 was lower in patients with cSS than in patients without cSS (OR 0.2; 95% CI 0.08–0.6; p = 0.0052) and lower in patients with disseminated cSS than in those with focal cSS (OR 0.02; 95% CI 0.003–0.2; p = 0.00057). Presence of cSS had no association with regard to ß-amyloid 40, total tau and phosphorylated tau.Conclusions: Our results demonstrate that the presence and extent of cSS are associated with reduced CSF ß-amyloid 42 levels. Further studies are needed to investigate the underlying mechanisms of this association. |
topic |
cerebral amyloid angiopathy cortical superficial siderosis cerebrospinal fluid cerebral microbleeds neuroimaging |
url |
https://www.frontiersin.org/article/10.3389/fneur.2019.00439/full |
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