Absence of Siglec-H in MCMV infection elevates interferon alpha production but does not enhance viral clearance.

Absence of Siglec-H in MCMV infection elevates interferon alpha production but does not enhance viral clearance.

Plasmacytoid dendritic cells (pDCs) express the I-type lectin receptor Siglec-H and produce interferon α (IFNα), a critical anti-viral cytokine during the acute phase of murine cytomegalovirus (MCMV) infection. The ligands and biological functions of Siglec-H still remain incompletely defined in viv...

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Main Authors: Franz Puttur, Catharina Arnold-Schrauf, Katharina Lahl, Gulhas Solmaz, Marc Lindenberg, Christian Thomas Mayer, Melanie Gohmert, Maxine Swallow, Christopher van Helt, Heike Schmitt, Lars Nitschke, Bart N Lambrecht, Roland Lang, Martin Messerle, Tim Sparwasser
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3784486?pdf=render

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