| Summary: | Four angucycline glycosides were previously characterized from marine-derived <i>Streptomyces</i> sp. OC1610.4. Further investigation of this strain cultured on different fermentation media from that used previously resulted in the isolation of two new angucycline glycosides, vineomycins E and F (<b>1</b>−<b>2</b>), and five known homologues, grincamycin L (<b>3</b>), vineomycinone B<sub>2</sub> (<b>4</b>), fridamycin D (<b>5</b>), moromycin B (<b>7</b>), and saquayamycin B<sub>1</sub> (<b>8</b>). Vineomycin F (<b>2</b>) contains an unusual ring-cleavage deoxy sugar. All the angucycline glycosides isolated from <i>Streptomyces</i> sp. OC1610.4 were evaluated for their cytotoxic activity against breast cancer cells MCF-7, MDA-MB-231, and BT-474. Moromycin B (<b>7</b>), saquayamycin B<sub>1</sub> (<b>8</b>), and saquayamycin B (<b>9</b>) displayed potent anti-proliferation against the tested cell lines, with IC<sub>50</sub> values ranging from 0.16 to 0.67 μM. Saquayamycin B (<b>9</b>) inhibited the migration and invasion of MDA-MB-231 cells in a dose-dependent manner, as detected by Transwell and wound-healing assays.
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