Factors Affecting Arsenic Methylation in Arsenic-Exposed Humans: A Systematic Review and Meta-Analysis
Chronic arsenic exposure is a critical public health issue in many countries. The metabolism of arsenic in vivo is complicated because it can be influenced by many factors. In the present meta-analysis, two researchers independently searched electronic databases, including the Cochrane Library, Pub...
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doaj-5dcb5ca59b5b4f318beca2e2531789aa2020-11-24T22:41:33ZengMDPI AGInternational Journal of Environmental Research and Public Health1660-46012016-02-0113220510.3390/ijerph13020205ijerph13020205Factors Affecting Arsenic Methylation in Arsenic-Exposed Humans: A Systematic Review and Meta-AnalysisHui Shen0Qiang Niu1Mengchuan Xu2Dongsheng Rui3Shangzhi Xu4Gangling Feng5Yusong Ding6Shugang Li7Mingxia Jing8Department of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, ChinaDepartment of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, ChinaDepartment of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, ChinaDepartment of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, ChinaDepartment of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, ChinaDepartment of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, ChinaDepartment of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, ChinaDepartment of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, ChinaDepartment of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, ChinaChronic arsenic exposure is a critical public health issue in many countries. The metabolism of arsenic in vivo is complicated because it can be influenced by many factors. In the present meta-analysis, two researchers independently searched electronic databases, including the Cochrane Library, PubMed, Springer, Embase, and China National Knowledge Infrastructure, to analyze factors influencing arsenic methylation. The concentrations of the following arsenic metabolites increase (p< 0.000001) following arsenic exposure: inorganic arsenic (iAs), monomethyl arsenic (MMA), dimethyl arsenic (DMA), and total arsenic. Additionally, the percentages of iAs (standard mean difference (SMD): 1.00; 95% confidence interval (CI): 0.60–1.40; p< 0.00001) and MMA (SMD: 0.49; 95% CI: 0.21–0.77; p = 0.0006) also increase, while the percentage of DMA (SMD: −0.57; 95% CI: −0.80–−0.31; p< 0.0001), primary methylation index (SMD: −0.57; 95% CI: −0.94–−0.20; p = 0.002), and secondary methylation index (SMD: −0.27; 95% CI: −0.46–−0.90; p = 0.004) decrease. Smoking, drinking, and older age can reduce arsenic methylation, and arsenic methylation is more efficient in women than in men. The results of this analysis may provide information regarding the role of arsenic oxidative methylation in the arsenic poisoning process.http://www.mdpi.com/1660-4601/13/2/205arsenicmethylationmeta-analysishuman |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hui Shen Qiang Niu Mengchuan Xu Dongsheng Rui Shangzhi Xu Gangling Feng Yusong Ding Shugang Li Mingxia Jing |
spellingShingle |
Hui Shen Qiang Niu Mengchuan Xu Dongsheng Rui Shangzhi Xu Gangling Feng Yusong Ding Shugang Li Mingxia Jing Factors Affecting Arsenic Methylation in Arsenic-Exposed Humans: A Systematic Review and Meta-Analysis International Journal of Environmental Research and Public Health arsenic methylation meta-analysis human |
author_facet |
Hui Shen Qiang Niu Mengchuan Xu Dongsheng Rui Shangzhi Xu Gangling Feng Yusong Ding Shugang Li Mingxia Jing |
author_sort |
Hui Shen |
title |
Factors Affecting Arsenic Methylation in Arsenic-Exposed Humans: A Systematic Review and Meta-Analysis |
title_short |
Factors Affecting Arsenic Methylation in Arsenic-Exposed Humans: A Systematic Review and Meta-Analysis |
title_full |
Factors Affecting Arsenic Methylation in Arsenic-Exposed Humans: A Systematic Review and Meta-Analysis |
title_fullStr |
Factors Affecting Arsenic Methylation in Arsenic-Exposed Humans: A Systematic Review and Meta-Analysis |
title_full_unstemmed |
Factors Affecting Arsenic Methylation in Arsenic-Exposed Humans: A Systematic Review and Meta-Analysis |
title_sort |
factors affecting arsenic methylation in arsenic-exposed humans: a systematic review and meta-analysis |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1660-4601 |
publishDate |
2016-02-01 |
description |
Chronic arsenic exposure is a critical public health issue in many countries. The metabolism of arsenic in vivo is complicated because it can be influenced by many factors. In the present meta-analysis, two researchers independently searched electronic databases, including the Cochrane Library, PubMed, Springer, Embase, and China National Knowledge Infrastructure, to analyze factors influencing arsenic methylation. The concentrations of the following arsenic metabolites increase (p< 0.000001) following arsenic exposure: inorganic arsenic (iAs), monomethyl arsenic (MMA), dimethyl arsenic (DMA), and total arsenic. Additionally, the percentages of iAs (standard mean difference (SMD): 1.00; 95% confidence interval (CI): 0.60–1.40; p< 0.00001) and MMA (SMD: 0.49; 95% CI: 0.21–0.77; p = 0.0006) also increase, while the percentage of DMA (SMD: −0.57; 95% CI: −0.80–−0.31; p< 0.0001), primary methylation index (SMD: −0.57; 95% CI: −0.94–−0.20; p = 0.002), and secondary methylation index (SMD: −0.27; 95% CI: −0.46–−0.90; p = 0.004) decrease. Smoking, drinking, and older age can reduce arsenic methylation, and arsenic methylation is more efficient in women than in men. The results of this analysis may provide information regarding the role of arsenic oxidative methylation in the arsenic poisoning process. |
topic |
arsenic methylation meta-analysis human |
url |
http://www.mdpi.com/1660-4601/13/2/205 |
work_keys_str_mv |
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