Generation and characterization of keap1a- and keap1b-knockout zebrafish

Generation and characterization of keap1a- and keap1b-knockout zebrafish

The Keap1–Nrf2 pathway is an evolutionarily conserved mechanism that protects cells from oxidative stress and electrophiles. Under homeostatic conditions, Keap1 interacts with Nrf2 and leads to its rapid proteasomal degradation, but when cells are exposed to oxidative stress/electrophiles, Keap1 sen...

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Bibliographic Details
Main Authors:	Vu Thanh Nguyen, Lixuan Bian, Junya Tamaoki, Shiro Otsubo, Masafumi Muratani, Atsuo Kawahara, Makoto Kobayashi
Format:	Article
Language:	English
Published:	Elsevier 2020-09-01
Series:	Redox Biology
Subjects:	Antioxidant activity Keap1–Nrf2 pathway Knockout zebrafish Oxidative stress Sulforaphane
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231720308727

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