A multifunctional peptide rescues memory deficits in Alzheimer's disease transgenic mice by inhibiting Aβ42-induced cytotoxicity and increasing microglial phagocytosis

A multifunctional peptide rescues memory deficits in Alzheimer's disease transgenic mice by inhibiting Aβ42-induced cytotoxicity and increasing microglial phagocytosis

Alzheimer's disease (AD) is characterized by progressive memory loss due to extracellular senile plaques and intracellular neurofibrillary tangles. The toxic β-amyloid (Aβ) aggregates that form in AD can induce the overproduction of reactive oxygen species (ROS), nitric oxide (NO), and proinfla...

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Bibliographic Details
Main Authors: Di Xue, Min Zhao, Yu-jiong Wang, Li Wang, Yang Yang, Shao-wei Wang, Ran Zhang, Yang Zhao, Rui-tian Liu
Format: Article
Language:English
Published: Elsevier 2012-06-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
β-Amyloid
Peptide
Cytotoxicity
Memory deficits
Aβ clearance
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112000848

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http://www.sciencedirect.com/science/article/pii/S0969996112000848

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