A multifunctional peptide rescues memory deficits in Alzheimer's disease transgenic mice by inhibiting Aβ42-induced cytotoxicity and increasing microglial phagocytosis
Alzheimer's disease (AD) is characterized by progressive memory loss due to extracellular senile plaques and intracellular neurofibrillary tangles. The toxic β-amyloid (Aβ) aggregates that form in AD can induce the overproduction of reactive oxygen species (ROS), nitric oxide (NO), and proinfla...
Main Authors: | Di Xue, Min Zhao, Yu-jiong Wang, Li Wang, Yang Yang, Shao-wei Wang, Ran Zhang, Yang Zhao, Rui-tian Liu |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2012-06-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996112000848 |
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