Evaluation of Skeletal Muscle Function and Effects of Early Rehabilitation during Acute Heart Failure: Rationale and Study Design
Background. Acute heart failure (AHF) is associated with disturbances of the peripheral perfusion leading to the dysfunction of many organs. Consequently, an episode of AHF constitutes a “multiple organ failure” which may also affect the skeletal muscles. However, the abnormalities within skeletal m...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2018-01-01
|
Series: | BioMed Research International |
Online Access: | http://dx.doi.org/10.1155/2018/6982897 |
id |
doaj-5e1ca8cf23034156877bf28c3e81d037 |
---|---|
record_format |
Article |
spelling |
doaj-5e1ca8cf23034156877bf28c3e81d0372020-11-24T23:47:50ZengHindawi LimitedBioMed Research International2314-61332314-61412018-01-01201810.1155/2018/69828976982897Evaluation of Skeletal Muscle Function and Effects of Early Rehabilitation during Acute Heart Failure: Rationale and Study DesignKinga Węgrzynowska-Teodorczyk0Agnieszka Siennicka1Krystian Josiak2Robert Zymliński3Monika Kasztura4Waldemar Banasiak5Piotr Ponikowski6Marek Woźniewski7Faculty of Physiotherapy, University of Physical Education in Wrocław, Wrocław, PolandCenter for Heart Disease, 4th Military Hospital of Wrocław, Wrocław, PolandCenter for Heart Disease, 4th Military Hospital of Wrocław, Wrocław, PolandCenter for Heart Disease, 4th Military Hospital of Wrocław, Wrocław, PolandDepartment of Heart Diseases, Wrocław Medical University, Wrocław, PolandCenter for Heart Disease, 4th Military Hospital of Wrocław, Wrocław, PolandCenter for Heart Disease, 4th Military Hospital of Wrocław, Wrocław, PolandFaculty of Physiotherapy, University of Physical Education in Wrocław, Wrocław, PolandBackground. Acute heart failure (AHF) is associated with disturbances of the peripheral perfusion leading to the dysfunction of many organs. Consequently, an episode of AHF constitutes a “multiple organ failure” which may also affect the skeletal muscles. However, the abnormalities within skeletal muscles during AHF have not been investigated so far. The aim of this project is to comprehensively evaluate skeletal muscles (at a functional and tissue level) during AHF. Methods. The study will include ≥63 consecutive AHF patients who will be randomized into 2 groups: ≥42 with cardiac rehabilitation group versus ≥21 with standard pharmacotherapy alone. The following tests will be conducted on the first and last day of hospitalization, at rest and after exercise, and 30 days following the discharge: clinical evaluation, medical interview, routine physical examination, echocardiography, and laboratory tests (including the assessment of NT-proBNP, inflammatory markers, and parameters reflecting the status of the kidneys and the liver); hemodynamic evaluation, noninvasive determination of cardiac output and systemic vascular resistance using the impedance cardiography; evaluation of biomarkers reflecting myocyte damage, immunochemical measurements of tissue-specific enzymatic isoforms; evaluation of skeletal muscle function, using surface electromyography (sEMG) (maximum tonus of the muscles will be determined along with the level of muscular fatigability); evaluation of muscle tissue perfusion, assessed on the basis of the oxygenation level, with noninvasive direct continuous recording of perfusion in peripheral tissues by local tissue oximetry, measured by near-infrared spectroscopy (NIRS). Results and Conclusions. Our findings will demonstrate that the muscle tissue is another area of the body which should be taken into consideration in the course of treatment of AHF, requiring a development of targeted therapeutic strategies, such as a properly conducted rehabilitation.http://dx.doi.org/10.1155/2018/6982897 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kinga Węgrzynowska-Teodorczyk Agnieszka Siennicka Krystian Josiak Robert Zymliński Monika Kasztura Waldemar Banasiak Piotr Ponikowski Marek Woźniewski |
spellingShingle |
Kinga Węgrzynowska-Teodorczyk Agnieszka Siennicka Krystian Josiak Robert Zymliński Monika Kasztura Waldemar Banasiak Piotr Ponikowski Marek Woźniewski Evaluation of Skeletal Muscle Function and Effects of Early Rehabilitation during Acute Heart Failure: Rationale and Study Design BioMed Research International |
author_facet |
Kinga Węgrzynowska-Teodorczyk Agnieszka Siennicka Krystian Josiak Robert Zymliński Monika Kasztura Waldemar Banasiak Piotr Ponikowski Marek Woźniewski |
author_sort |
Kinga Węgrzynowska-Teodorczyk |
title |
Evaluation of Skeletal Muscle Function and Effects of Early Rehabilitation during Acute Heart Failure: Rationale and Study Design |
title_short |
Evaluation of Skeletal Muscle Function and Effects of Early Rehabilitation during Acute Heart Failure: Rationale and Study Design |
title_full |
Evaluation of Skeletal Muscle Function and Effects of Early Rehabilitation during Acute Heart Failure: Rationale and Study Design |
title_fullStr |
Evaluation of Skeletal Muscle Function and Effects of Early Rehabilitation during Acute Heart Failure: Rationale and Study Design |
title_full_unstemmed |
Evaluation of Skeletal Muscle Function and Effects of Early Rehabilitation during Acute Heart Failure: Rationale and Study Design |
title_sort |
evaluation of skeletal muscle function and effects of early rehabilitation during acute heart failure: rationale and study design |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2018-01-01 |
description |
Background. Acute heart failure (AHF) is associated with disturbances of the peripheral perfusion leading to the dysfunction of many organs. Consequently, an episode of AHF constitutes a “multiple organ failure” which may also affect the skeletal muscles. However, the abnormalities within skeletal muscles during AHF have not been investigated so far. The aim of this project is to comprehensively evaluate skeletal muscles (at a functional and tissue level) during AHF. Methods. The study will include ≥63 consecutive AHF patients who will be randomized into 2 groups: ≥42 with cardiac rehabilitation group versus ≥21 with standard pharmacotherapy alone. The following tests will be conducted on the first and last day of hospitalization, at rest and after exercise, and 30 days following the discharge: clinical evaluation, medical interview, routine physical examination, echocardiography, and laboratory tests (including the assessment of NT-proBNP, inflammatory markers, and parameters reflecting the status of the kidneys and the liver); hemodynamic evaluation, noninvasive determination of cardiac output and systemic vascular resistance using the impedance cardiography; evaluation of biomarkers reflecting myocyte damage, immunochemical measurements of tissue-specific enzymatic isoforms; evaluation of skeletal muscle function, using surface electromyography (sEMG) (maximum tonus of the muscles will be determined along with the level of muscular fatigability); evaluation of muscle tissue perfusion, assessed on the basis of the oxygenation level, with noninvasive direct continuous recording of perfusion in peripheral tissues by local tissue oximetry, measured by near-infrared spectroscopy (NIRS). Results and Conclusions. Our findings will demonstrate that the muscle tissue is another area of the body which should be taken into consideration in the course of treatment of AHF, requiring a development of targeted therapeutic strategies, such as a properly conducted rehabilitation. |
url |
http://dx.doi.org/10.1155/2018/6982897 |
work_keys_str_mv |
AT kingawegrzynowskateodorczyk evaluationofskeletalmusclefunctionandeffectsofearlyrehabilitationduringacuteheartfailurerationaleandstudydesign AT agnieszkasiennicka evaluationofskeletalmusclefunctionandeffectsofearlyrehabilitationduringacuteheartfailurerationaleandstudydesign AT krystianjosiak evaluationofskeletalmusclefunctionandeffectsofearlyrehabilitationduringacuteheartfailurerationaleandstudydesign AT robertzymlinski evaluationofskeletalmusclefunctionandeffectsofearlyrehabilitationduringacuteheartfailurerationaleandstudydesign AT monikakasztura evaluationofskeletalmusclefunctionandeffectsofearlyrehabilitationduringacuteheartfailurerationaleandstudydesign AT waldemarbanasiak evaluationofskeletalmusclefunctionandeffectsofearlyrehabilitationduringacuteheartfailurerationaleandstudydesign AT piotrponikowski evaluationofskeletalmusclefunctionandeffectsofearlyrehabilitationduringacuteheartfailurerationaleandstudydesign AT marekwozniewski evaluationofskeletalmusclefunctionandeffectsofearlyrehabilitationduringacuteheartfailurerationaleandstudydesign |
_version_ |
1725488396873236480 |