Reliable identification of protein-protein interactions by crosslinking mass spectrometry
Cross-linking mass spectrometry (MS) can identify protein-protein interaction (PPI) networks but assessing the reliability of these data remains challenging. To address this issue, the authors develop and validate a method to determine the false-discovery rate of PPIs identified by cross-linking MS.
Main Authors: | Swantje Lenz, Ludwig R. Sinn, Francis J. O’Reilly, Lutz Fischer, Fritz Wegner, Juri Rappsilber |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-06-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-021-23666-z |
Similar Items
-
Retention time prediction using neural networks increases identifications in crosslinking mass spectrometry
by: Sven H. Giese, et al.
Published: (2021-05-01) -
An integrated workflow for crosslinking mass spectrometry
by: Marta L Mendes, et al.
Published: (2019-09-01) -
Protein complex architecture from mass spectrometry, crosslinking and informatics
by: Taverner, Thomas
Published: (2007) -
Multi-Protein Complexes Studied by Mass Spectrometry
by: Jens S. Andersen, et al.
Published: (2002-01-01) -
Chemical crosslinking and mass spectrometry to elucidate the topology of integral membrane proteins.
by: Mykhaylo O Debelyy, et al.
Published: (2017-01-01)