Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis

Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis

Despite many angiogenic factors playing crucial roles in metabolic homeostasis, effects of angiopoietin-2 (ANG-2) in adipose tissue (AT) remain unclear. Utilizing a doxycycline-inducible AT-specific ANG-2 overexpression mouse model, we assessed the effects of ANG-2 in AT expansion upon a high-fat di...

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Bibliographic Details
Main Authors: Yu A An, Kai Sun, Nolwenn Joffin, Fang Zhang, Yingfeng Deng, Olivier Donzé, Christine M Kusminski, Philipp E Scherer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-03-01
Series:eLife
Subjects:
adipose tissue expansion
angiogenesis
Angiopoietin-2
obesity
metabolic homeostasis
Online Access:https://elifesciences.org/articles/24071

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