A recombinant fusion toxin based on enzymatic inactive C3bot1 selectively targets macrophages.
BACKGROUND: The C3bot1 protein (~23 kDa) from Clostridium botulinum ADP-ribosylates and thereby inactivates Rho. C3bot1 is selectively taken up into the cytosol of monocytes/macrophages but not of other cell types such as epithelial cells or fibroblasts. Most likely, the internalization occurs by a...
Main Authors: | Lydia Dmochewitz, Christina Förtsch, Christian Zwerger, Martin Vaeth, Edward Felder, Markus Huber-Lang, Holger Barth |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3549961?pdf=render |
Similar Items
-
C3 rho-inhibitor for targeted pharmacological manipulation of osteoclast-like cells.
by: Andrea Tautzenberger, et al.
Published: (2013-01-01) -
Clostridial C3 toxins target monocytes/macrophages and modulate their functions
by: Holger eBarth, et al.
Published: (2015-06-01) -
Inhibition of ERBB2-overexpressing Tumors by Recombinant Human Prolidase and Its Enzymatically Inactive Mutant
by: Lu Yang, et al.
Published: (2015-05-01) -
An Introduction to the Toxins Special Issue on “Novel Pharmacological Inhibitors for Bacterial Protein Toxins”
by: Holger Barth
Published: (2017-05-01) -
Expression of enzymatically inactive wasp venom phospholipase A1 in Pichia pastoris.
by: Irina Borodina, et al.
Published: (2011-01-01)