Lipofilling in Breast Oncological Surgery: A Safe Opportunity or Risk for Cancer Recurrence?
Lipofilling (LF) is a largely employed technique in reconstructive and esthetic breast surgery. Over the years, it has demonstrated to be extremely useful for treatment of soft tissue defects after demolitive or conservative breast cancer surgery and different procedures have been developed to impro...
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doaj-5e29feab487c41deb14e00dbe1b784cd2021-04-03T23:00:48ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-04-01223737373710.3390/ijms22073737Lipofilling in Breast Oncological Surgery: A Safe Opportunity or Risk for Cancer Recurrence?Francesca Piccotti0Ilona Rybinska1Elisabetta Scoccia2Carlo Morasso3Alessandra Ricciardi4Lorena Signati5Tiziana Triulzi6Fabio Corsi7Marta Truffi8Laboratorio di Nanomedicina ed Imaging Molecolare, Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, ItalyMolecular Targeting Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, ItalyBreast Unit, Surgery Department, Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, ItalyLaboratorio di Nanomedicina ed Imaging Molecolare, Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, ItalyLaboratorio di Nanomedicina ed Imaging Molecolare, Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, ItalyDipartimento di Scienze Biomediche e Cliniche “L. Sacco”, Università Degli Studi di Milano, 20157 Milano, ItalyMolecular Targeting Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, ItalyBreast Unit, Surgery Department, Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, ItalyLaboratorio di Nanomedicina ed Imaging Molecolare, Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, ItalyLipofilling (LF) is a largely employed technique in reconstructive and esthetic breast surgery. Over the years, it has demonstrated to be extremely useful for treatment of soft tissue defects after demolitive or conservative breast cancer surgery and different procedures have been developed to improve the survival of transplanted fat graft. The regenerative potential of LF is attributed to the multipotent stem cells found in large quantity in adipose tissue. However, a growing body of pre-clinical evidence shows that adipocytes and adipose-derived stromal cells may have pro-tumorigenic potential. Despite no clear indication from clinical studies has demonstrated an increased risk of cancer recurrence upon LF, these observations challenge the oncologic safety of the procedure. This review aims to provide an updated overview of both the clinical and the pre-clinical indications to the suitability and safety of LF in breast oncological surgery. Cellular and molecular players in the crosstalk between adipose tissue and cancer are described, and heterogeneous contradictory results are discussed, highlighting that important issues still remain to be solved to get a clear understanding of LF safety in breast cancer patients.https://www.mdpi.com/1422-0067/22/7/3737lipofillingbreast reconstructionadipose tissueadipose-derived stromal cellsbreast canceroncological safety |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Francesca Piccotti Ilona Rybinska Elisabetta Scoccia Carlo Morasso Alessandra Ricciardi Lorena Signati Tiziana Triulzi Fabio Corsi Marta Truffi |
spellingShingle |
Francesca Piccotti Ilona Rybinska Elisabetta Scoccia Carlo Morasso Alessandra Ricciardi Lorena Signati Tiziana Triulzi Fabio Corsi Marta Truffi Lipofilling in Breast Oncological Surgery: A Safe Opportunity or Risk for Cancer Recurrence? International Journal of Molecular Sciences lipofilling breast reconstruction adipose tissue adipose-derived stromal cells breast cancer oncological safety |
author_facet |
Francesca Piccotti Ilona Rybinska Elisabetta Scoccia Carlo Morasso Alessandra Ricciardi Lorena Signati Tiziana Triulzi Fabio Corsi Marta Truffi |
author_sort |
Francesca Piccotti |
title |
Lipofilling in Breast Oncological Surgery: A Safe Opportunity or Risk for Cancer Recurrence? |
title_short |
Lipofilling in Breast Oncological Surgery: A Safe Opportunity or Risk for Cancer Recurrence? |
title_full |
Lipofilling in Breast Oncological Surgery: A Safe Opportunity or Risk for Cancer Recurrence? |
title_fullStr |
Lipofilling in Breast Oncological Surgery: A Safe Opportunity or Risk for Cancer Recurrence? |
title_full_unstemmed |
Lipofilling in Breast Oncological Surgery: A Safe Opportunity or Risk for Cancer Recurrence? |
title_sort |
lipofilling in breast oncological surgery: a safe opportunity or risk for cancer recurrence? |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-04-01 |
description |
Lipofilling (LF) is a largely employed technique in reconstructive and esthetic breast surgery. Over the years, it has demonstrated to be extremely useful for treatment of soft tissue defects after demolitive or conservative breast cancer surgery and different procedures have been developed to improve the survival of transplanted fat graft. The regenerative potential of LF is attributed to the multipotent stem cells found in large quantity in adipose tissue. However, a growing body of pre-clinical evidence shows that adipocytes and adipose-derived stromal cells may have pro-tumorigenic potential. Despite no clear indication from clinical studies has demonstrated an increased risk of cancer recurrence upon LF, these observations challenge the oncologic safety of the procedure. This review aims to provide an updated overview of both the clinical and the pre-clinical indications to the suitability and safety of LF in breast oncological surgery. Cellular and molecular players in the crosstalk between adipose tissue and cancer are described, and heterogeneous contradictory results are discussed, highlighting that important issues still remain to be solved to get a clear understanding of LF safety in breast cancer patients. |
topic |
lipofilling breast reconstruction adipose tissue adipose-derived stromal cells breast cancer oncological safety |
url |
https://www.mdpi.com/1422-0067/22/7/3737 |
work_keys_str_mv |
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