Cardiorespiratory responses to low-level ozone exposure: The inDoor Ozone Study in childrEn (DOSE)
Background: Indoor air pollution has emerged as a significant environmental and public health concern in recent years. However, evidence regarding the cardiorespiratory effects of indoor ozone is limited, and the underlying biological mechanisms are unclear, especially in children. Our study aimed t...
Main Authors: | , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2019-10-01
|
Series: | Environment International |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412019314308 |
id |
doaj-5e2d6eca70fc4f03b07f788d00d7688b |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jing Huang Yi Song Mengtian Chu Wei Dong Mark R. Miller Miranda Loh Junhui Xu Di Yang Rui Chi Xuan Yang Shaowei Wu Xinbiao Guo Furong Deng |
spellingShingle |
Jing Huang Yi Song Mengtian Chu Wei Dong Mark R. Miller Miranda Loh Junhui Xu Di Yang Rui Chi Xuan Yang Shaowei Wu Xinbiao Guo Furong Deng Cardiorespiratory responses to low-level ozone exposure: The inDoor Ozone Study in childrEn (DOSE) Environment International |
author_facet |
Jing Huang Yi Song Mengtian Chu Wei Dong Mark R. Miller Miranda Loh Junhui Xu Di Yang Rui Chi Xuan Yang Shaowei Wu Xinbiao Guo Furong Deng |
author_sort |
Jing Huang |
title |
Cardiorespiratory responses to low-level ozone exposure: The inDoor Ozone Study in childrEn (DOSE) |
title_short |
Cardiorespiratory responses to low-level ozone exposure: The inDoor Ozone Study in childrEn (DOSE) |
title_full |
Cardiorespiratory responses to low-level ozone exposure: The inDoor Ozone Study in childrEn (DOSE) |
title_fullStr |
Cardiorespiratory responses to low-level ozone exposure: The inDoor Ozone Study in childrEn (DOSE) |
title_full_unstemmed |
Cardiorespiratory responses to low-level ozone exposure: The inDoor Ozone Study in childrEn (DOSE) |
title_sort |
cardiorespiratory responses to low-level ozone exposure: the indoor ozone study in children (dose) |
publisher |
Elsevier |
series |
Environment International |
issn |
0160-4120 |
publishDate |
2019-10-01 |
description |
Background: Indoor air pollution has emerged as a significant environmental and public health concern in recent years. However, evidence regarding the cardiorespiratory effects of indoor ozone is limited, and the underlying biological mechanisms are unclear, especially in children. Our study aimed to assess the cardiorespiratory responses to indoor ozone exposure in children. Methods: A repeated-measure study was conducted in 46 middle-school children in Beijing, China. Real-time concentrations of ozone, along with co-pollutants including particulate matter (PM) and black carbon (BC), were monitored in classrooms from Monday to Friday. Three repeated health measurements of cardiorespiratory functions, including ambulatory electrocardiogram (ECG), blood pressure, fractional exhaled nitric oxide (FeNO) and lung function, were performed on each participant. Mixed-effect models were used to evaluate the effects of indoor ozone exposure. Results: The mean (SD) indoor ozone concentration was 8.7 (6.6) ppb during the study period, which was largely below the current guideline and standards. However, even this low-level ozone exposure was associated with reduced cardiac autonomic function and increased heart rate (HR) in children. For instance, per interquartile range (IQR) increase in ozone at 2-hour moving average was associated with −7.8% (95% CI: −9.9%, −5.6%) reduction in standard deviation of all normal-to-normal intervals (SDNN), and 2.6% (95% CI: 1.6%, 3.6%) increment in HR. In addition, the associations were stronger at high BC levels (BC ≥ 3.7 μg/m3). No significant associations were found for airway inflammation and pulmonary function. Conclusions: Exposure to low-level indoor ozone that is not associated with respiratory effects was significantly related to disturbed cardiac autonomic function and increased HR in children, which suggested a possible mechanism through which ozone may affect cardiovascular health in children, and indicated more protective measures should be taken to alleviate the acute adverse effects of indoor ozone in this susceptible population. Keywords: Indoor exposure, Low-level ozone, Children, Cardiorespiratory responses |
url |
http://www.sciencedirect.com/science/article/pii/S0160412019314308 |
work_keys_str_mv |
AT jinghuang cardiorespiratoryresponsestolowlevelozoneexposuretheindoorozonestudyinchildrendose AT yisong cardiorespiratoryresponsestolowlevelozoneexposuretheindoorozonestudyinchildrendose AT mengtianchu cardiorespiratoryresponsestolowlevelozoneexposuretheindoorozonestudyinchildrendose AT weidong cardiorespiratoryresponsestolowlevelozoneexposuretheindoorozonestudyinchildrendose AT markrmiller cardiorespiratoryresponsestolowlevelozoneexposuretheindoorozonestudyinchildrendose AT mirandaloh cardiorespiratoryresponsestolowlevelozoneexposuretheindoorozonestudyinchildrendose AT junhuixu cardiorespiratoryresponsestolowlevelozoneexposuretheindoorozonestudyinchildrendose AT diyang cardiorespiratoryresponsestolowlevelozoneexposuretheindoorozonestudyinchildrendose AT ruichi cardiorespiratoryresponsestolowlevelozoneexposuretheindoorozonestudyinchildrendose AT xuanyang cardiorespiratoryresponsestolowlevelozoneexposuretheindoorozonestudyinchildrendose AT shaoweiwu cardiorespiratoryresponsestolowlevelozoneexposuretheindoorozonestudyinchildrendose AT xinbiaoguo cardiorespiratoryresponsestolowlevelozoneexposuretheindoorozonestudyinchildrendose AT furongdeng cardiorespiratoryresponsestolowlevelozoneexposuretheindoorozonestudyinchildrendose |
_version_ |
1725130289845370880 |
spelling |
doaj-5e2d6eca70fc4f03b07f788d00d7688b2020-11-25T01:21:25ZengElsevierEnvironment International0160-41202019-10-01131Cardiorespiratory responses to low-level ozone exposure: The inDoor Ozone Study in childrEn (DOSE)Jing Huang0Yi Song1Mengtian Chu2Wei Dong3Mark R. Miller4Miranda Loh5Junhui Xu6Di Yang7Rui Chi8Xuan Yang9Shaowei Wu10Xinbiao Guo11Furong Deng12Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, ChinaInstitute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, ChinaDepartment of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, ChinaDepartment of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, ChinaUniversity/BHF Centre for Cardiovascular Science, Queens Medical Research Institute, The University of Edinburgh, Edinburgh, UKInstitute of Occupational Medicine, Research Avenue North, Riccarton, Edinburgh, UKDepartment of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, ChinaDepartment of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, ChinaDepartment of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, ChinaDepartment of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, ChinaDepartment of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, ChinaDepartment of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, China; Corresponding authors at: Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, No. 38 Xueyuan Road, Beijing 100191, China.Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, China; Corresponding authors at: Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, No. 38 Xueyuan Road, Beijing 100191, China.Background: Indoor air pollution has emerged as a significant environmental and public health concern in recent years. However, evidence regarding the cardiorespiratory effects of indoor ozone is limited, and the underlying biological mechanisms are unclear, especially in children. Our study aimed to assess the cardiorespiratory responses to indoor ozone exposure in children. Methods: A repeated-measure study was conducted in 46 middle-school children in Beijing, China. Real-time concentrations of ozone, along with co-pollutants including particulate matter (PM) and black carbon (BC), were monitored in classrooms from Monday to Friday. Three repeated health measurements of cardiorespiratory functions, including ambulatory electrocardiogram (ECG), blood pressure, fractional exhaled nitric oxide (FeNO) and lung function, were performed on each participant. Mixed-effect models were used to evaluate the effects of indoor ozone exposure. Results: The mean (SD) indoor ozone concentration was 8.7 (6.6) ppb during the study period, which was largely below the current guideline and standards. However, even this low-level ozone exposure was associated with reduced cardiac autonomic function and increased heart rate (HR) in children. For instance, per interquartile range (IQR) increase in ozone at 2-hour moving average was associated with −7.8% (95% CI: −9.9%, −5.6%) reduction in standard deviation of all normal-to-normal intervals (SDNN), and 2.6% (95% CI: 1.6%, 3.6%) increment in HR. In addition, the associations were stronger at high BC levels (BC ≥ 3.7 μg/m3). No significant associations were found for airway inflammation and pulmonary function. Conclusions: Exposure to low-level indoor ozone that is not associated with respiratory effects was significantly related to disturbed cardiac autonomic function and increased HR in children, which suggested a possible mechanism through which ozone may affect cardiovascular health in children, and indicated more protective measures should be taken to alleviate the acute adverse effects of indoor ozone in this susceptible population. Keywords: Indoor exposure, Low-level ozone, Children, Cardiorespiratory responseshttp://www.sciencedirect.com/science/article/pii/S0160412019314308 |