Interhemispherically dynamic representation of an eye movement-related activity in mouse frontal cortex
Cortical plasticity is fundamental to motor recovery following cortical perturbation. However, it is still unclear how this plasticity is induced at a functional circuit level. Here, we investigated motor recovery and underlying neural plasticity upon optogenetic suppression of a cortical area for e...
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doaj-5e3e13bc65b947d5bcca7b90eeb39cb82021-05-05T18:04:22ZengeLife Sciences Publications LtdeLife2050-084X2019-11-01810.7554/eLife.50855Interhemispherically dynamic representation of an eye movement-related activity in mouse frontal cortexTakashi R Sato0https://orcid.org/0000-0002-7623-9021Takahide Itokazu1Hironobu Osaki2https://orcid.org/0000-0001-9780-0810Makoto Ohtake3Tetsuya Yamamoto4Kazuhiro Sohya5Takakuni Maki6Tatsuo K Sato7https://orcid.org/0000-0002-1279-5125Department of Neuroscience, Medical University of South Carolina, Charleston, United States; Center for Integrative Neuroscience, University of Tübingen, Tübingen, Germany; Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan; JST, PRESTO, Kawaguchi, JapanCenter for Integrative Neuroscience, University of Tübingen, Tübingen, Germany; Department of Neuro-Medical Science, Osaka University, Osaka, JapanCenter for Integrative Neuroscience, University of Tübingen, Tübingen, Germany; Department of Physiology, Tokyo Women’s Medical University, Tokyo, JapanDepartment of Neuroscience, Medical University of South Carolina, Charleston, United States; Department of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama, JapanDepartment of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama, JapanDepartment of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, JapanDepartment of Neurology, Kyoto University Graduate School of Medicine, Kyoto, JapanJST, PRESTO, Kawaguchi, Japan; Department of Physiology, Monash University, Clayton, Australia; Neuroscience Program, Biomedicine Discovery Institute, Monash University, Clayton, AustraliaCortical plasticity is fundamental to motor recovery following cortical perturbation. However, it is still unclear how this plasticity is induced at a functional circuit level. Here, we investigated motor recovery and underlying neural plasticity upon optogenetic suppression of a cortical area for eye movement. Using a visually-guided eye movement task in mice, we suppressed a portion of the secondary motor cortex (MOs) that encodes contraversive eye movement. Optogenetic unilateral suppression severely impaired contraversive movement on the first day. However, on subsequent days the suppression became inefficient and capability for the movement was restored. Longitudinal two-photon calcium imaging revealed that the regained capability was accompanied by an increased number of neurons encoding for ipsiversive movement in the unsuppressed contralateral MOs. Additional suppression of the contralateral MOs impaired the recovered movement again, indicating a compensatory mechanism. Our findings demonstrate that repeated optogenetic suppression leads to functional recovery mediated by the contralateral hemisphere.https://elifesciences.org/articles/50855motor cortexeye movementplasticity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Takashi R Sato Takahide Itokazu Hironobu Osaki Makoto Ohtake Tetsuya Yamamoto Kazuhiro Sohya Takakuni Maki Tatsuo K Sato |
spellingShingle |
Takashi R Sato Takahide Itokazu Hironobu Osaki Makoto Ohtake Tetsuya Yamamoto Kazuhiro Sohya Takakuni Maki Tatsuo K Sato Interhemispherically dynamic representation of an eye movement-related activity in mouse frontal cortex eLife motor cortex eye movement plasticity |
author_facet |
Takashi R Sato Takahide Itokazu Hironobu Osaki Makoto Ohtake Tetsuya Yamamoto Kazuhiro Sohya Takakuni Maki Tatsuo K Sato |
author_sort |
Takashi R Sato |
title |
Interhemispherically dynamic representation of an eye movement-related activity in mouse frontal cortex |
title_short |
Interhemispherically dynamic representation of an eye movement-related activity in mouse frontal cortex |
title_full |
Interhemispherically dynamic representation of an eye movement-related activity in mouse frontal cortex |
title_fullStr |
Interhemispherically dynamic representation of an eye movement-related activity in mouse frontal cortex |
title_full_unstemmed |
Interhemispherically dynamic representation of an eye movement-related activity in mouse frontal cortex |
title_sort |
interhemispherically dynamic representation of an eye movement-related activity in mouse frontal cortex |
publisher |
eLife Sciences Publications Ltd |
series |
eLife |
issn |
2050-084X |
publishDate |
2019-11-01 |
description |
Cortical plasticity is fundamental to motor recovery following cortical perturbation. However, it is still unclear how this plasticity is induced at a functional circuit level. Here, we investigated motor recovery and underlying neural plasticity upon optogenetic suppression of a cortical area for eye movement. Using a visually-guided eye movement task in mice, we suppressed a portion of the secondary motor cortex (MOs) that encodes contraversive eye movement. Optogenetic unilateral suppression severely impaired contraversive movement on the first day. However, on subsequent days the suppression became inefficient and capability for the movement was restored. Longitudinal two-photon calcium imaging revealed that the regained capability was accompanied by an increased number of neurons encoding for ipsiversive movement in the unsuppressed contralateral MOs. Additional suppression of the contralateral MOs impaired the recovered movement again, indicating a compensatory mechanism. Our findings demonstrate that repeated optogenetic suppression leads to functional recovery mediated by the contralateral hemisphere. |
topic |
motor cortex eye movement plasticity |
url |
https://elifesciences.org/articles/50855 |
work_keys_str_mv |
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