The Role of Probiotics and Prebiotics in the Prevention and Treatment of Obesity
Obesity is a global pandemic complex to treat due to its multifactorial pathogenesis—an unhealthy lifestyle, neuronal and hormonal mechanisms, and genetic and epigenetic factors are involved. Scientific evidence supports the idea that obesity and metabolic consequences are strongly related...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-03-01
|
Series: | Nutrients |
Subjects: | |
Online Access: | http://www.mdpi.com/2072-6643/11/3/635 |
id |
doaj-5e441c95a68248299040d86cf56b78c6 |
---|---|
record_format |
Article |
spelling |
doaj-5e441c95a68248299040d86cf56b78c62020-11-24T23:56:50ZengMDPI AGNutrients2072-66432019-03-0111363510.3390/nu11030635nu11030635The Role of Probiotics and Prebiotics in the Prevention and Treatment of ObesityTomás Cerdó0José Antonio García-Santos1Mercedes G. Bermúdez2Cristina Campoy3Department of Pediatrics, School of Medicine, University of Granada, Avda. Investigación 11, 18016 Granada, SpainDepartment of Pediatrics, School of Medicine, University of Granada, Avda. Investigación 11, 18016 Granada, SpainDepartment of Pediatrics, School of Medicine, University of Granada, Avda. Investigación 11, 18016 Granada, SpainDepartment of Pediatrics, School of Medicine, University of Granada, Avda. Investigación 11, 18016 Granada, SpainObesity is a global pandemic complex to treat due to its multifactorial pathogenesis—an unhealthy lifestyle, neuronal and hormonal mechanisms, and genetic and epigenetic factors are involved. Scientific evidence supports the idea that obesity and metabolic consequences are strongly related to changes in both the function and composition of gut microbiota, which exert an essential role in modulating energy metabolism. Modifications of gut microbiota composition have been associated with variations in body weight and body mass index. Lifestyle modifications remain as primary therapy for obesity and related metabolic disorders. New therapeutic strategies to treat/prevent obesity have been proposed, based on pre- and/or probiotic modulation of gut microbiota to mimic that found in healthy non-obese subjects. Based on human and animal studies, this review aimed to discuss mechanisms through which gut microbiota could act as a key modifier of obesity and related metabolic complications. Evidence from animal studies and human clinical trials suggesting potential beneficial effects of prebiotic and various probiotic strains on those physical, biochemical, and metabolic parameters related to obesity is presented. As a conclusion, a deeper knowledge about pre-/probiotic mechanisms of action, in combination with adequately powered, randomized controlled follow-up studies, will facilitate the clinical application and development of personalized healthcare strategies.http://www.mdpi.com/2072-6643/11/3/635obesitygut microbiotaprobioticsprebioticsnutrition |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tomás Cerdó José Antonio García-Santos Mercedes G. Bermúdez Cristina Campoy |
spellingShingle |
Tomás Cerdó José Antonio García-Santos Mercedes G. Bermúdez Cristina Campoy The Role of Probiotics and Prebiotics in the Prevention and Treatment of Obesity Nutrients obesity gut microbiota probiotics prebiotics nutrition |
author_facet |
Tomás Cerdó José Antonio García-Santos Mercedes G. Bermúdez Cristina Campoy |
author_sort |
Tomás Cerdó |
title |
The Role of Probiotics and Prebiotics in the Prevention and Treatment of Obesity |
title_short |
The Role of Probiotics and Prebiotics in the Prevention and Treatment of Obesity |
title_full |
The Role of Probiotics and Prebiotics in the Prevention and Treatment of Obesity |
title_fullStr |
The Role of Probiotics and Prebiotics in the Prevention and Treatment of Obesity |
title_full_unstemmed |
The Role of Probiotics and Prebiotics in the Prevention and Treatment of Obesity |
title_sort |
role of probiotics and prebiotics in the prevention and treatment of obesity |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2019-03-01 |
description |
Obesity is a global pandemic complex to treat due to its multifactorial pathogenesis—an unhealthy lifestyle, neuronal and hormonal mechanisms, and genetic and epigenetic factors are involved. Scientific evidence supports the idea that obesity and metabolic consequences are strongly related to changes in both the function and composition of gut microbiota, which exert an essential role in modulating energy metabolism. Modifications of gut microbiota composition have been associated with variations in body weight and body mass index. Lifestyle modifications remain as primary therapy for obesity and related metabolic disorders. New therapeutic strategies to treat/prevent obesity have been proposed, based on pre- and/or probiotic modulation of gut microbiota to mimic that found in healthy non-obese subjects. Based on human and animal studies, this review aimed to discuss mechanisms through which gut microbiota could act as a key modifier of obesity and related metabolic complications. Evidence from animal studies and human clinical trials suggesting potential beneficial effects of prebiotic and various probiotic strains on those physical, biochemical, and metabolic parameters related to obesity is presented. As a conclusion, a deeper knowledge about pre-/probiotic mechanisms of action, in combination with adequately powered, randomized controlled follow-up studies, will facilitate the clinical application and development of personalized healthcare strategies. |
topic |
obesity gut microbiota probiotics prebiotics nutrition |
url |
http://www.mdpi.com/2072-6643/11/3/635 |
work_keys_str_mv |
AT tomascerdo theroleofprobioticsandprebioticsinthepreventionandtreatmentofobesity AT joseantoniogarciasantos theroleofprobioticsandprebioticsinthepreventionandtreatmentofobesity AT mercedesgbermudez theroleofprobioticsandprebioticsinthepreventionandtreatmentofobesity AT cristinacampoy theroleofprobioticsandprebioticsinthepreventionandtreatmentofobesity AT tomascerdo roleofprobioticsandprebioticsinthepreventionandtreatmentofobesity AT joseantoniogarciasantos roleofprobioticsandprebioticsinthepreventionandtreatmentofobesity AT mercedesgbermudez roleofprobioticsandprebioticsinthepreventionandtreatmentofobesity AT cristinacampoy roleofprobioticsandprebioticsinthepreventionandtreatmentofobesity |
_version_ |
1725456338941640704 |