Detection of subclinical skin manifestation in patients with psoriasis and psoriatic arthritis by fluorescence optical imaging
Abstract Objectives To investigate the frequency of subclinical skin inflammation in both hands by fluorescence optical imaging (FOI) in patients with psoriasis/psoriatic arthritis (Pso/PsA) vs. rheumatoid arthritis (RA) and healthy individuals, and to correlate these findings with cardiovascular (C...
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doaj-5e44a585e18744e09bff7d70a1b044672020-11-25T03:49:37ZengBMCArthritis Research & Therapy1478-63622020-08-012211910.1186/s13075-020-02277-xDetection of subclinical skin manifestation in patients with psoriasis and psoriatic arthritis by fluorescence optical imagingA. Schmidt0A. M. Glimm1I. K. Haugen2P. Hoff3G. Schmittat4G. R. Burmester5J. Klotsche6S. Ohrndorf7Department of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin BerlinDepartment of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin BerlinDepartment of Rheumatology, Diakonhjemmet HospitalDepartment of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin BerlinDepartment of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin BerlinDepartment of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin BerlinDeutsches Rheumaforschungszentrum (DRFZ) Berlin, A Leibnitz InstituteDepartment of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin BerlinAbstract Objectives To investigate the frequency of subclinical skin inflammation in both hands by fluorescence optical imaging (FOI) in patients with psoriasis/psoriatic arthritis (Pso/PsA) vs. rheumatoid arthritis (RA) and healthy individuals, and to correlate these findings with cardiovascular (CV) risk factors. Patients and methods The FOI scans were analyzed retrospectively to detect clinically invisible skin enhancement (0–3 scale) in both hands without relationship to underlying joints or blood vessels. We further characterized the FOI patterns and sorted the scans into groups based on the assumed diagnosis (Pso/PsA, RA, and healthy controls), which was compared with the physician’s diagnosis. Furthermore, the associations between CV risk factors and imaging findings were investigated by regression analyses. Results We included FOI scans of patients with Pso/PsA (n = 80), RA (n = 78), and healthy controls (n = 25). Subclinical skin enhancement on the back of their hands was more common in Pso/PsA (72.5%) than in RA patients (20.5%) and healthy individuals (28.0%) (p < 0.001). Based on the FOI pattern, the majority of patients with Pso/PsA (72.5%), RA (76.9%), and healthy controls (68.0%) were classified correctly using the physician-based diagnosis as reference (overall agreement of 74%, kappa = 0.57). No CV risk factors except body weight (kg) were associated with subclinical skin enhancement (OR 1.04, 95% CI 1.02–1.06; p < 0.001). Conclusion Subclinical subdermal skin inflammation was common in Pso/PsA patients using FOI. Based on the FOI pattern, most patients with Pso/PsA and were classified with the correct diagnosis. We demonstrated an important influence of the body weight on our FOI results. FOI may be a helpful novel tool to study microcirculation in rheumatic diseases with skin involvement.http://link.springer.com/article/10.1186/s13075-020-02277-xPsoriasis vulgarisPsoriatic arthritisSkin inflammationFluorescence optical imagingCardiovascular risk factors |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
A. Schmidt A. M. Glimm I. K. Haugen P. Hoff G. Schmittat G. R. Burmester J. Klotsche S. Ohrndorf |
spellingShingle |
A. Schmidt A. M. Glimm I. K. Haugen P. Hoff G. Schmittat G. R. Burmester J. Klotsche S. Ohrndorf Detection of subclinical skin manifestation in patients with psoriasis and psoriatic arthritis by fluorescence optical imaging Arthritis Research & Therapy Psoriasis vulgaris Psoriatic arthritis Skin inflammation Fluorescence optical imaging Cardiovascular risk factors |
author_facet |
A. Schmidt A. M. Glimm I. K. Haugen P. Hoff G. Schmittat G. R. Burmester J. Klotsche S. Ohrndorf |
author_sort |
A. Schmidt |
title |
Detection of subclinical skin manifestation in patients with psoriasis and psoriatic arthritis by fluorescence optical imaging |
title_short |
Detection of subclinical skin manifestation in patients with psoriasis and psoriatic arthritis by fluorescence optical imaging |
title_full |
Detection of subclinical skin manifestation in patients with psoriasis and psoriatic arthritis by fluorescence optical imaging |
title_fullStr |
Detection of subclinical skin manifestation in patients with psoriasis and psoriatic arthritis by fluorescence optical imaging |
title_full_unstemmed |
Detection of subclinical skin manifestation in patients with psoriasis and psoriatic arthritis by fluorescence optical imaging |
title_sort |
detection of subclinical skin manifestation in patients with psoriasis and psoriatic arthritis by fluorescence optical imaging |
publisher |
BMC |
series |
Arthritis Research & Therapy |
issn |
1478-6362 |
publishDate |
2020-08-01 |
description |
Abstract Objectives To investigate the frequency of subclinical skin inflammation in both hands by fluorescence optical imaging (FOI) in patients with psoriasis/psoriatic arthritis (Pso/PsA) vs. rheumatoid arthritis (RA) and healthy individuals, and to correlate these findings with cardiovascular (CV) risk factors. Patients and methods The FOI scans were analyzed retrospectively to detect clinically invisible skin enhancement (0–3 scale) in both hands without relationship to underlying joints or blood vessels. We further characterized the FOI patterns and sorted the scans into groups based on the assumed diagnosis (Pso/PsA, RA, and healthy controls), which was compared with the physician’s diagnosis. Furthermore, the associations between CV risk factors and imaging findings were investigated by regression analyses. Results We included FOI scans of patients with Pso/PsA (n = 80), RA (n = 78), and healthy controls (n = 25). Subclinical skin enhancement on the back of their hands was more common in Pso/PsA (72.5%) than in RA patients (20.5%) and healthy individuals (28.0%) (p < 0.001). Based on the FOI pattern, the majority of patients with Pso/PsA (72.5%), RA (76.9%), and healthy controls (68.0%) were classified correctly using the physician-based diagnosis as reference (overall agreement of 74%, kappa = 0.57). No CV risk factors except body weight (kg) were associated with subclinical skin enhancement (OR 1.04, 95% CI 1.02–1.06; p < 0.001). Conclusion Subclinical subdermal skin inflammation was common in Pso/PsA patients using FOI. Based on the FOI pattern, most patients with Pso/PsA and were classified with the correct diagnosis. We demonstrated an important influence of the body weight on our FOI results. FOI may be a helpful novel tool to study microcirculation in rheumatic diseases with skin involvement. |
topic |
Psoriasis vulgaris Psoriatic arthritis Skin inflammation Fluorescence optical imaging Cardiovascular risk factors |
url |
http://link.springer.com/article/10.1186/s13075-020-02277-x |
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