Scavenger Receptor Class B type 1 (SR-B1) and the modifiable risk factors of stroke

• Main Authors: Cameron Lenahan, Lei Huang, Zachary D. Travis, John H. Zhang
• Format: Article
• Language: English
• Published: BMC 2019-12-01
• Series: Chinese Neurosurgical Journal
• Subjects: Scavenger Receptor Class B type 1; SR-B1; Atherosclerosis; Coronary heart disease; Diabetes mellitus; Sickle cell
• Online Access: https://doi.org/10.1186/s41016-019-0178-3

Abstract Stroke is a devastating disease that occurs when a blood vessel in the brain is either blocked or ruptured, consequently leading to deficits in neurological function. Stroke consistently ranked as one of the top causes of mortality, and with the mean age of incidence decreasing, there is renewed interest to seek novel therapeutic treatments. The Scavenger Receptor Class B type 1 (SR-B1) is a multifunctional protein found on the surface of a variety of cells. Research has found that that SR-B1 primarily functions in an anti-inflammatory and anti-atherosclerotic capacity. In this review, we discuss the characteristics of SR-B1 and focus on its potential correlation with the modifiable risk factors of stroke. SR-B1 likely has an impact on stroke through its interaction with smoking, diabetes mellitus, diet, physical inactivity, obesity, hypercholesterolemia, atherosclerosis, coronary heart disease, hypertension, and sickle cell disease, all of which are critical risk factors in the pathogenesis of stroke.