Inner lumen proteins stabilize doublet microtubules in cilia and flagella

Inner lumen proteins stabilize doublet microtubules in cilia and flagella

Microtubules in cilia are sufficiently stable to withstand the beating motion, but how they are stabilized while serving as tracks for intraflagellar transport and axonemal dyneins remains unknown. Here authors identify two microtubule inner proteins, FAP45 and FAP52, which stabilize the ciliary axo...

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Main Authors: Mikito Owa, Takayuki Uchihashi, Haru-aki Yanagisawa, Takashi Yamano, Hiro Iguchi, Hideya Fukuzawa, Ken-ichi Wakabayashi, Toshio Ando, Masahide Kikkawa
Format: Article
Language:English
Published: Nature Publishing Group 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09051-x
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spelling doaj-5e612bec25a646c4a808060c4891ba902021-05-11T11:29:24ZengNature Publishing GroupNature Communications2041-17232019-03-0110111010.1038/s41467-019-09051-xInner lumen proteins stabilize doublet microtubules in cilia and flagellaMikito Owa0Takayuki Uchihashi1Haru-aki Yanagisawa2Takashi Yamano3Hiro Iguchi4Hideya Fukuzawa5Ken-ichi Wakabayashi6Toshio Ando7Masahide Kikkawa8Department of Cell Biology and Anatomy, Graduate School of Medicine, The University of TokyoDepartment of Physics and Structural Biology Research Center, Chikusa-ku, Nagoya UniversityDepartment of Cell Biology and Anatomy, Graduate School of Medicine, The University of TokyoGraduate School of Biostudies, Kyoto UniversityGraduate School of Biostudies, Kyoto UniversityGraduate School of Biostudies, Kyoto UniversityLaboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of TechnologyWPI Nano Life Science Institute, Kanazawa UniversityDepartment of Cell Biology and Anatomy, Graduate School of Medicine, The University of TokyoMicrotubules in cilia are sufficiently stable to withstand the beating motion, but how they are stabilized while serving as tracks for intraflagellar transport and axonemal dyneins remains unknown. Here authors identify two microtubule inner proteins, FAP45 and FAP52, which stabilize the ciliary axonemes in Chlamydomonas.https://doi.org/10.1038/s41467-019-09051-x
collection DOAJ
language English
format Article
sources DOAJ
author Mikito Owa
Takayuki Uchihashi
Haru-aki Yanagisawa
Takashi Yamano
Hiro Iguchi
Hideya Fukuzawa
Ken-ichi Wakabayashi
Toshio Ando
Masahide Kikkawa
spellingShingle Mikito Owa
Takayuki Uchihashi
Haru-aki Yanagisawa
Takashi Yamano
Hiro Iguchi
Hideya Fukuzawa
Ken-ichi Wakabayashi
Toshio Ando
Masahide Kikkawa
Inner lumen proteins stabilize doublet microtubules in cilia and flagella
Nature Communications
author_facet Mikito Owa
Takayuki Uchihashi
Haru-aki Yanagisawa
Takashi Yamano
Hiro Iguchi
Hideya Fukuzawa
Ken-ichi Wakabayashi
Toshio Ando
Masahide Kikkawa
author_sort Mikito Owa
title Inner lumen proteins stabilize doublet microtubules in cilia and flagella
title_short Inner lumen proteins stabilize doublet microtubules in cilia and flagella
title_full Inner lumen proteins stabilize doublet microtubules in cilia and flagella
title_fullStr Inner lumen proteins stabilize doublet microtubules in cilia and flagella
title_full_unstemmed Inner lumen proteins stabilize doublet microtubules in cilia and flagella
title_sort inner lumen proteins stabilize doublet microtubules in cilia and flagella
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-03-01
description Microtubules in cilia are sufficiently stable to withstand the beating motion, but how they are stabilized while serving as tracks for intraflagellar transport and axonemal dyneins remains unknown. Here authors identify two microtubule inner proteins, FAP45 and FAP52, which stabilize the ciliary axonemes in Chlamydomonas.
url https://doi.org/10.1038/s41467-019-09051-x
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AT takayukiuchihashi innerlumenproteinsstabilizedoubletmicrotubulesinciliaandflagella
AT haruakiyanagisawa innerlumenproteinsstabilizedoubletmicrotubulesinciliaandflagella
AT takashiyamano innerlumenproteinsstabilizedoubletmicrotubulesinciliaandflagella
AT hiroiguchi innerlumenproteinsstabilizedoubletmicrotubulesinciliaandflagella
AT hideyafukuzawa innerlumenproteinsstabilizedoubletmicrotubulesinciliaandflagella
AT kenichiwakabayashi innerlumenproteinsstabilizedoubletmicrotubulesinciliaandflagella
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AT masahidekikkawa innerlumenproteinsstabilizedoubletmicrotubulesinciliaandflagella
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