A quantitative Streptococcus pyogenes–human protein–protein interaction map reveals localization of opsonizing antibodies
Characterizing host-pathogen protein interactions can help elucidate the molecular basis of bacterial infections. Here, the authors use an integrative proteomics approach to generate a quantitative map of protein interactions between Streptococcus pyogenes and human saliva and plasma.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10583-5 |
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doaj-5e6b3b9bfaf4481895310369f23b17c52021-05-11T11:37:16ZengNature Publishing GroupNature Communications2041-17232019-06-0110111510.1038/s41467-019-10583-5A quantitative Streptococcus pyogenes–human protein–protein interaction map reveals localization of opsonizing antibodiesLotta Happonen0Simon Hauri1Gabriel Svensson Birkedal2Christofer Karlsson3Therese de Neergaard4Hamed Khakzad5Pontus Nordenfelt6Mats Wikström7Magdalena Wisniewska8Lars Björck9Lars Malmström10Johan Malmström11Lund University, Faculty of Medicine, Department of Clinical Sciences, Division of Infection Medicine, Lund UniversityLund University, Faculty of Medicine, Department of Clinical Sciences, Division of Infection Medicine, Lund UniversityLund University, Faculty of Medicine, Department of Clinical Sciences, Division of Infection Medicine, Lund UniversityLund University, Faculty of Medicine, Department of Clinical Sciences, Division of Infection Medicine, Lund UniversityLund University, Faculty of Medicine, Department of Clinical Sciences, Division of Infection Medicine, Lund UniversityS3IT, University of ZurichLund University, Faculty of Medicine, Department of Clinical Sciences, Division of Infection Medicine, Lund UniversityNovo Nordisk Foundation Center for Protein Research, University of CopenhagenNovo Nordisk Foundation Center for Protein Research, University of CopenhagenLund University, Faculty of Medicine, Department of Clinical Sciences, Division of Infection Medicine, Lund UniversityLund University, Faculty of Medicine, Department of Clinical Sciences, Division of Infection Medicine, Lund UniversityLund University, Faculty of Medicine, Department of Clinical Sciences, Division of Infection Medicine, Lund UniversityCharacterizing host-pathogen protein interactions can help elucidate the molecular basis of bacterial infections. Here, the authors use an integrative proteomics approach to generate a quantitative map of protein interactions between Streptococcus pyogenes and human saliva and plasma.https://doi.org/10.1038/s41467-019-10583-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Lotta Happonen Simon Hauri Gabriel Svensson Birkedal Christofer Karlsson Therese de Neergaard Hamed Khakzad Pontus Nordenfelt Mats Wikström Magdalena Wisniewska Lars Björck Lars Malmström Johan Malmström |
| spellingShingle |
Lotta Happonen Simon Hauri Gabriel Svensson Birkedal Christofer Karlsson Therese de Neergaard Hamed Khakzad Pontus Nordenfelt Mats Wikström Magdalena Wisniewska Lars Björck Lars Malmström Johan Malmström A quantitative Streptococcus pyogenes–human protein–protein interaction map reveals localization of opsonizing antibodies Nature Communications |
| author_facet |
Lotta Happonen Simon Hauri Gabriel Svensson Birkedal Christofer Karlsson Therese de Neergaard Hamed Khakzad Pontus Nordenfelt Mats Wikström Magdalena Wisniewska Lars Björck Lars Malmström Johan Malmström |
| author_sort |
Lotta Happonen |
| title |
A quantitative Streptococcus pyogenes–human protein–protein interaction map reveals localization of opsonizing antibodies |
| title_short |
A quantitative Streptococcus pyogenes–human protein–protein interaction map reveals localization of opsonizing antibodies |
| title_full |
A quantitative Streptococcus pyogenes–human protein–protein interaction map reveals localization of opsonizing antibodies |
| title_fullStr |
A quantitative Streptococcus pyogenes–human protein–protein interaction map reveals localization of opsonizing antibodies |
| title_full_unstemmed |
A quantitative Streptococcus pyogenes–human protein–protein interaction map reveals localization of opsonizing antibodies |
| title_sort |
quantitative streptococcus pyogenes–human protein–protein interaction map reveals localization of opsonizing antibodies |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-06-01 |
| description |
Characterizing host-pathogen protein interactions can help elucidate the molecular basis of bacterial infections. Here, the authors use an integrative proteomics approach to generate a quantitative map of protein interactions between Streptococcus pyogenes and human saliva and plasma. |
| url |
https://doi.org/10.1038/s41467-019-10583-5 |
| work_keys_str_mv |
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