Plasma cholesterol lowering action of bile acid binding polymers in experimental animals

Plasma cholesterol lowering action of bile acid binding polymers in experimental animals

Feeding of bile acid binding polymeric organic bases inhibited cholesterol rise and aortic. plaque formation in cholesterol-fed cockerels, lowered plasma cholesterol concentrations in normocholesterolemic cockerels and dogs, and increased fecal bile acid and sterol output in a dog. In experiments la...

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Main Authors: DavidM. Tennent, Henry Siegel, MaryE. Zanetti, GuntherW. Kuron, WaltherH. Ott, FrankJ. Wolf
Format: Article
Language:English
Published: Elsevier 1960-10-01
Series:Journal of Lipid Research
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520412350
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spelling doaj-5e6c57290b01484ca6d090eefdd5fb422021-04-23T06:13:23ZengElsevierJournal of Lipid Research0022-22751960-10-0115469473Plasma cholesterol lowering action of bile acid binding polymers in experimental animalsDavidM. Tennent0Henry Siegel1MaryE. Zanetti2GuntherW. Kuron3WaltherH. Ott4FrankJ. Wolf5Merck Institute for Therapeutic Research and the Merck Sharp & Dohme Research Laboratories, Rahway, New JerseyMerck Institute for Therapeutic Research and the Merck Sharp & Dohme Research Laboratories, Rahway, New JerseyMerck Institute for Therapeutic Research and the Merck Sharp & Dohme Research Laboratories, Rahway, New JerseyMerck Institute for Therapeutic Research and the Merck Sharp & Dohme Research Laboratories, Rahway, New JerseyMerck Institute for Therapeutic Research and the Merck Sharp & Dohme Research Laboratories, Rahway, New JerseyMerck Institute for Therapeutic Research and the Merck Sharp & Dohme Research Laboratories, Rahway, New JerseyFeeding of bile acid binding polymeric organic bases inhibited cholesterol rise and aortic. plaque formation in cholesterol-fed cockerels, lowered plasma cholesterol concentrations in normocholesterolemic cockerels and dogs, and increased fecal bile acid and sterol output in a dog. In experiments lasting as long as one year these substances have not produced visible toxic effects. They are thought to act by binding the bile acids in the intestinal tract.http://www.sciencedirect.com/science/article/pii/S0022227520412350
collection DOAJ
language English
format Article
sources DOAJ
author DavidM. Tennent
Henry Siegel
MaryE. Zanetti
GuntherW. Kuron
WaltherH. Ott
FrankJ. Wolf
spellingShingle DavidM. Tennent
Henry Siegel
MaryE. Zanetti
GuntherW. Kuron
WaltherH. Ott
FrankJ. Wolf
Plasma cholesterol lowering action of bile acid binding polymers in experimental animals
Journal of Lipid Research
author_facet DavidM. Tennent
Henry Siegel
MaryE. Zanetti
GuntherW. Kuron
WaltherH. Ott
FrankJ. Wolf
author_sort DavidM. Tennent
title Plasma cholesterol lowering action of bile acid binding polymers in experimental animals
title_short Plasma cholesterol lowering action of bile acid binding polymers in experimental animals
title_full Plasma cholesterol lowering action of bile acid binding polymers in experimental animals
title_fullStr Plasma cholesterol lowering action of bile acid binding polymers in experimental animals
title_full_unstemmed Plasma cholesterol lowering action of bile acid binding polymers in experimental animals
title_sort plasma cholesterol lowering action of bile acid binding polymers in experimental animals
publisher Elsevier
series Journal of Lipid Research
issn 0022-2275
publishDate 1960-10-01
description Feeding of bile acid binding polymeric organic bases inhibited cholesterol rise and aortic. plaque formation in cholesterol-fed cockerels, lowered plasma cholesterol concentrations in normocholesterolemic cockerels and dogs, and increased fecal bile acid and sterol output in a dog. In experiments lasting as long as one year these substances have not produced visible toxic effects. They are thought to act by binding the bile acids in the intestinal tract.
url http://www.sciencedirect.com/science/article/pii/S0022227520412350
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AT henrysiegel plasmacholesterolloweringactionofbileacidbindingpolymersinexperimentalanimals
AT maryezanetti plasmacholesterolloweringactionofbileacidbindingpolymersinexperimentalanimals
AT guntherwkuron plasmacholesterolloweringactionofbileacidbindingpolymersinexperimentalanimals
AT waltherhott plasmacholesterolloweringactionofbileacidbindingpolymersinexperimentalanimals
AT frankjwolf plasmacholesterolloweringactionofbileacidbindingpolymersinexperimentalanimals
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